8A9I
PI3KC2a core in complex with PITCOIN1
Summary for 8A9I
Entry DOI | 10.2210/pdb8a9i/pdb |
Related | 7Z74 7Z75 |
Descriptor | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, 2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-~{N}-(1,3-thiazol-2-yl)ethanamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | pi3kc2 alpha, kinase, transferase |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 1 |
Total formula weight | 103130.72 |
Authors | Lo, W.T.,Roske, Y.,Daumke, O.,Haucke, V. (deposition date: 2022-06-28, release date: 2022-08-31, Last modification date: 2024-01-31) |
Primary citation | Lo, W.T.,Belabed, H.,Kucukdisli, M.,Metag, J.,Roske, Y.,Prokofeva, P.,Ohashi, Y.,Horatscheck, A.,Cirillo, D.,Krauss, M.,Schmied, C.,Neuenschwander, M.,von Kries, J.P.,Medard, G.,Kuster, B.,Perisic, O.,Williams, R.L.,Daumke, O.,Payrastre, B.,Severin, S.,Nazare, M.,Haucke, V. Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha. Nat.Chem.Biol., 19:18-27, 2023 Cited by PubMed: 36109648DOI: 10.1038/s41589-022-01118-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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