5INE
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![BU of 5ine by Molmil](/molmil-images/mine/5ine) | Crystal structure of the prefusion glycoprotein of LCMV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pre-glycoprotein polyprotein GP complex, ... | Authors: | Hastie, K.M, Saphire, E.O. | Deposit date: | 2016-03-07 | Release date: | 2016-04-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV. Nat.Struct.Mol.Biol., 23, 2016
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4FVU
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![BU of 4fvu by Molmil](/molmil-images/mine/4fvu) | Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease | Descriptor: | MAGNESIUM ION, Nucleoprotein, RNA (5'-R(*CP*UP*CP*CP*CP*UP*CP*C)-3'), ... | Authors: | Hastie, K.M, King, L.B, Zandonatti, M.A, Saphire, E.O. | Deposit date: | 2012-06-29 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease. Plos One, 7, 2012
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5VK2
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![BU of 5vk2 by Molmil](/molmil-images/mine/5vk2) | Structural basis for antibody-mediated neutralization of Lassa virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hastie, K.M, Zandonatti, M.A, Kleinfelter, L.M, Rowland, M.L, Rowland, M.M, Chandra, K, Branco, L.M, Robinson, J.E, Garry, R.F, Saphire, E.O. | Deposit date: | 2017-04-20 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | Structural basis for antibody-mediated neutralization of Lassa virus. Science, 356, 2017
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3T5Q
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![BU of 3t5q by Molmil](/molmil-images/mine/3t5q) | 3A structure of Lassa virus nucleoprotein in complex with ssRNA | Descriptor: | Nucleoprotein, PHOSPHATE ION, RNA (5'-R(P*UP*AP*UP*CP*UP*C)-3'), ... | Authors: | Hastie, K.M, Liu, T, King, L.B, Ngo, N, Zandonatti, M.A, Woods, V.L, de la Torre, J.C, Saphire, E.O. | Deposit date: | 2011-07-27 | Release date: | 2012-01-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding. Proc.Natl.Acad.Sci.USA, 108, 2011
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7S8H
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![BU of 7s8h by Molmil](/molmil-images/mine/7s8h) | |
3Q7C
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![BU of 3q7c by Molmil](/molmil-images/mine/3q7c) | Exonuclease domain of Lassa virus nucleoprotein bound to manganese | Descriptor: | MANGANESE (II) ION, Nucleoprotein, PHOSPHATE ION, ... | Authors: | Hastie, K.M, Kimberlin, C.R, Zandonatti, M.A, MacRae, I.J, Saphire, E.O. | Deposit date: | 2011-01-04 | Release date: | 2011-02-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proc.Natl.Acad.Sci.USA, 108, 2011
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3Q7B
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![BU of 3q7b by Molmil](/molmil-images/mine/3q7b) | Exonuclease domain of Lassa virus nucleoprotein | Descriptor: | Nucleoprotein, PHOSPHATE ION, ZINC ION | Authors: | Hastie, K.M, Kimberlin, C.R, Zandonatti, M.A, MacRae, I.J, Saphire, E.O. | Deposit date: | 2011-01-04 | Release date: | 2011-02-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proc.Natl.Acad.Sci.USA, 108, 2011
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5I72
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![BU of 5i72 by Molmil](/molmil-images/mine/5i72) | Crystal structure of the oligomeric form of the Lassa virus matrix protein Z | Descriptor: | RING finger protein Z, ZINC ION | Authors: | Hastie, K, Zandonatti, M, Liu, T, Li, S, Woods Jr, V, Saphire, E.O. | Deposit date: | 2016-02-16 | Release date: | 2016-03-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z. J.Virol., 90, 2016
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3T5N
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![BU of 3t5n by Molmil](/molmil-images/mine/3t5n) | 1.8A crystal structure of Lassa virus nucleoprotein in complex with ssRNA | Descriptor: | NICKEL (II) ION, Nucleoprotein, RNA (5'-R(P*UP*AP*UP*CP*UP*C)-3') | Authors: | Hastie, K.M, Liu, T, King, L.B, Ngo, N, Zandonatti, M.A, Woods, V.L, de la Torre, J.C, Saphire, E.O. | Deposit date: | 2011-07-27 | Release date: | 2012-01-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.787 Å) | Cite: | Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding. Proc.Natl.Acad.Sci.USA, 108, 2011
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7S8G
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![BU of 7s8g by Molmil](/molmil-images/mine/7s8g) | |
6BP2
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![BU of 6bp2 by Molmil](/molmil-images/mine/6bp2) | Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ... | Authors: | King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O. | Deposit date: | 2017-11-21 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.172 Å) | Cite: | The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe, 23, 2018
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4O6H
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![BU of 4o6h by Molmil](/molmil-images/mine/4o6h) | 2.8A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain | Descriptor: | IMIDAZOLE, MAGNESIUM ION, Nucleoprotein, ... | Authors: | West, B.R, Hastie, K.M, Saphire, E.O. | Deposit date: | 2013-12-20 | Release date: | 2014-06-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. Acta Crystallogr.,Sect.D, 70, 2014
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6P95
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![BU of 6p95 by Molmil](/molmil-images/mine/6p95) | Structure of Lassa virus glycoprotein in complex with Fab 25.6A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Saphire, E.O, Hastie, K.M. | Deposit date: | 2019-06-09 | Release date: | 2019-09-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization. Cell, 178, 2019
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4O6I
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![BU of 4o6i by Molmil](/molmil-images/mine/4o6i) | 2.0A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain | Descriptor: | IMIDAZOLE, MAGNESIUM ION, Nucleoprotein, ... | Authors: | West, B.R, Hastie, K.M, Saphire, E.O. | Deposit date: | 2013-12-20 | Release date: | 2014-06-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. Acta Crystallogr.,Sect.D, 70, 2014
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6P91
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![BU of 6p91 by Molmil](/molmil-images/mine/6p91) | Structure of Lassa virus glycoprotein bound to Fab 18.5C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 18.5C Antibody heavy chain, ... | Authors: | Saphire, E.O, Hastie, K.M. | Deposit date: | 2019-06-09 | Release date: | 2019-08-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization. Cell, 178, 2019
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5KEL
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![BU of 5kel by Molmil](/molmil-images/mine/5kel) | EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ebola surface glycoprotein, ... | Authors: | Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B. | Deposit date: | 2016-06-09 | Release date: | 2016-09-07 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structures of Ebola virus GP and sGP in complex with therapeutic antibodies. Nat Microbiol, 1, 2016
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5KEN
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![BU of 5ken by Molmil](/molmil-images/mine/5ken) | EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ebola surface glycoprotein, ... | Authors: | Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B. | Deposit date: | 2016-06-09 | Release date: | 2016-09-07 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structures of Ebola virus GP and sGP in complex with therapeutic antibodies. Nat Microbiol, 1, 2016
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7UL7
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![BU of 7ul7 by Molmil](/molmil-images/mine/7ul7) | Lineage I (Pinneo) Lassa virus glycoprotein bound to 18.5C-M30 Fab | Descriptor: | 18.5C-M30 Fab Heavy Chain, 18.5C-M30 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Buck, T.K, Enriquez, A.S, Hastie, K.M. | Deposit date: | 2022-04-04 | Release date: | 2022-06-15 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Neutralizing Antibodies against Lassa Virus Lineage I. Mbio, 13, 2022
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7UDS
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![BU of 7uds by Molmil](/molmil-images/mine/7uds) | Structure of lineage I (Pinneo) Lassa virus glycoprotein bound to Fab 25.10C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 25.10C Fab Heavy Chain, ... | Authors: | Buck, T.K, Enriquez, A.E, Hastie, K.M. | Deposit date: | 2022-03-20 | Release date: | 2022-06-15 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Neutralizing Antibodies against Lassa Virus Lineage I. Mbio, 13, 2022
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7TYV
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![BU of 7tyv by Molmil](/molmil-images/mine/7tyv) | Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 25.10C Fab Heavy Chain, ... | Authors: | Enriquez, A.S, Hastie, K.M. | Deposit date: | 2022-02-14 | Release date: | 2022-06-01 | Last modified: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies. Cell Rep, 39, 2022
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5KEM
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![BU of 5kem by Molmil](/molmil-images/mine/5kem) | EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91 | Descriptor: | BDBV91 variable Fab domain heavy chain, BDBV91 variable Fab domain light chain, Ebola secreted glycoprotein, ... | Authors: | Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B. | Deposit date: | 2016-06-09 | Release date: | 2016-09-07 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Structures of Ebola virus GP and sGP in complex with therapeutic antibodies. Nat Microbiol, 1, 2016
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8E1G
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![BU of 8e1g by Molmil](/molmil-images/mine/8e1g) | SARS-CoV-2 RBD in complex with Omicron-neutralizing antibody 2A10 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2A10 Fab, heavy chain, ... | Authors: | Wasserman, H, Hastie, K.M, Buck, T.K, Saphire, E.O. | Deposit date: | 2022-08-10 | Release date: | 2023-06-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep, 42, 2023
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8F0G
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![BU of 8f0g by Molmil](/molmil-images/mine/8f0g) | Structure of SARS-CoV-2 Omicron BA.1 spike in complex with antibody Fab 1C3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 1C3 Fab Heavy Chain, ... | Authors: | Yu, X, Zyla, D, Hastie, K.M, Saphire, E.O. | Deposit date: | 2022-11-02 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep, 42, 2023
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8DMH
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![BU of 8dmh by Molmil](/molmil-images/mine/8dmh) | Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28 | Descriptor: | 18.5C-M28 Fab Heavy Chain, 18.5C-M28 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Moon-Walker, A, Hastie, K.M, Zyla, D.S, Saphire, E.O. | Deposit date: | 2022-07-08 | Release date: | 2023-04-12 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chem Biol, 30, 2023
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8F0H
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![BU of 8f0h by Molmil](/molmil-images/mine/8f0h) | Structure of SARS-CoV-2 spike with antibody Fabs 2A10 and 1H2 (Local refinement of the RBD and Fabs 1H2 and 2A10) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 1H2 heavy chain, Antibody Fab 1H2 light chain, ... | Authors: | Yu, X, Zyla, D, Hastie, K.M, Saphire, E.O. | Deposit date: | 2022-11-02 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Rep, 42, 2023
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