4O6H

2.8A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain

Summary for 4O6H

Entry DOI	10.2210/pdb4o6h/pdb
Related	4O6I
Descriptor	Nucleoprotein, ZINC ION, IMIDAZOLE, ... (5 entities in total)
Functional Keywords	exoribonuclease, hydrolase
Biological source	Lymphocytic choriomeningitis virus (LCMV)
Cellular location	Virion: P09992
Total number of polymer chains	8
Total formula weight	212254.38
Authors	West, B.R.,Hastie, K.M.,Saphire, E.O. (deposition date: 2013-12-20, release date: 2014-06-11, Last modification date: 2023-09-20)
Primary citation	West, B.R.,Hastie, K.M.,Saphire, E.O. Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. Acta Crystallogr.,Sect.D, 70:1764-1769, 2014 Cited by PubMed Abstract: The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus. PubMed: 24914986 DOI: 10.1107/S1399004714007883 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation