5I72

Crystal structure of the oligomeric form of the Lassa virus matrix protein Z

Summary for 5I72

Entry DOI	10.2210/pdb5i72/pdb
Descriptor	RING finger protein Z, ZINC ION (2 entities in total)
Functional Keywords	arenavirus, lassa virus, matrix, z, oligomer, viral protein
Biological source	Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)
Cellular location	Virion: O73557
Total number of polymer chains	2
Total formula weight	12432.29
Authors	Hastie, K.,Zandonatti, M.,Liu, T.,Li, S.,Woods Jr, V.,Saphire, E.O. (deposition date: 2016-02-16, release date: 2016-03-09, Last modification date: 2024-05-22)
Primary citation	Hastie, K.M.,Zandonatti, M.,Liu, T.,Li, S.,Woods, V.L.,Saphire, E.O. Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z. J.Virol., 90:4556-4562, 2016 Cited by PubMed Abstract: The arenavirus matrix protein Z is highly multifunctional and occurs in both monomeric and oligomeric forms. The crystal structure of a dodecamer of Z from Lassa virus, presented here, illustrates a ring-like structure with a highly basic center. Mutagenesis demonstrates that the dimeric interface within the dodecamer and a Lys-Trp-Lys triad at the center of the ring are important for oligomerization. This structure provides an additional template to explore the many functions of Z. PubMed: 26912609 DOI: 10.1128/JVI.02896-15 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation