6BFC
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![BU of 6bfc by Molmil](/molmil-images/mine/6bfc) | Cryo-EM structure of human insulin degrading enzyme in complex with insulin | Descriptor: | Insulin, Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-26 | Release date: | 2017-12-27 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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6B3Q
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![BU of 6b3q by Molmil](/molmil-images/mine/6b3q) | Cryo-EM structure of human insulin degrading enzyme in complex with insulin | Descriptor: | Insulin, Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-09-22 | Release date: | 2017-11-22 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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6BF6
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![BU of 6bf6 by Molmil](/molmil-images/mine/6bf6) | Cryo-EM structure of human insulin degrading enzyme | Descriptor: | Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-26 | Release date: | 2018-02-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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6B7Z
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![BU of 6b7z by Molmil](/molmil-images/mine/6b7z) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain | Descriptor: | FAB H11 heavy chain, FAB H11 light chain, Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-05 | Release date: | 2018-01-10 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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6BF9
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![BU of 6bf9 by Molmil](/molmil-images/mine/6bf9) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | Descriptor: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-26 | Release date: | 2018-02-07 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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6BF7
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![BU of 6bf7 by Molmil](/molmil-images/mine/6bf7) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | Descriptor: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-26 | Release date: | 2018-02-07 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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8J86
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![BU of 8j86 by Molmil](/molmil-images/mine/8j86) | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in a DNA binding form | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3'), DNA (5'-D(P*GP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*GP*AP*TP*AP*AP*CP*TP*TP*AP*AP*TP*CP*TP*CP*AP*CP*AP*TP*AP*GP*CP*AP*GP*CP*TP*)-3'), ... | Authors: | Xu, Y, Wu, Y, Wu, X, Zhang, Y, Yang, Y, Li, D, Yang, B, Gao, K, Zhang, Z, Dong, C. | Deposit date: | 2023-04-30 | Release date: | 2024-05-01 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir. Int.J.Biol.Macromol., 270, 2024
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8J8F
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![BU of 8j8f by Molmil](/molmil-images/mine/8j8f) | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 in complex with a DNA duplex and dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3'), ... | Authors: | Xu, Y, Wu, Y, Wu, X, Zhang, Y, Yang, Y, Li, D, Yang, B, Gao, K, Zhang, Z, Dong, C. | Deposit date: | 2023-05-01 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir. Int.J.Biol.Macromol., 270, 2024
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5BX1
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![BU of 5bx1 by Molmil](/molmil-images/mine/5bx1) | Crystal Structure of PRL-1 complex with compound analogy 3 | Descriptor: | 3-(5,6-dimethyl-2H-isoindol-2-yl)-N'-[(E)-furan-2-ylmethylidene]benzohydrazide, Protein tyrosine phosphatase type IVA 1, SULFATE ION | Authors: | Liu, S, Bai, Y, Zhang, Z. | Deposit date: | 2015-06-08 | Release date: | 2016-12-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of PRL-1 complex with compound analogy 3 To Be Published
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7U5J
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![BU of 7u5j by Molmil](/molmil-images/mine/7u5j) | Cryo-EM Structure of ALDOA | Descriptor: | Fructose-bisphosphate aldolase | Authors: | Morgan, C.E, Zhang, Z, Yu, E.W. | Deposit date: | 2022-03-02 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Toward structural-omics of the bovine retinal pigment epithelium. Cell Rep, 41, 2022
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7U5M
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![BU of 7u5m by Molmil](/molmil-images/mine/7u5m) | Cryo-EM Structure of GAPDH | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Morgan, C.E, Zhang, Z, Yu, E.W. | Deposit date: | 2022-03-02 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.28 Å) | Cite: | Toward structural-omics of the bovine retinal pigment epithelium. Cell Rep, 41, 2022
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7U5N
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7U5I
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7KKH
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![BU of 7kkh by Molmil](/molmil-images/mine/7kkh) | P1A4 Fab in complex with ARS1620 | Descriptor: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, P1A4 Fab Heavy Chain, P1A4 Fab Light Chain, ... | Authors: | Basu, K, Rohweder, P.J, Zhang, Z, Bohn, M.-F, Shokat, K, Craik, C.S. | Deposit date: | 2020-10-27 | Release date: | 2022-04-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy. Cancer Cell, 40, 2022
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7XR4
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7XR6
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![BU of 7xr6 by Molmil](/molmil-images/mine/7xr6) | Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613 | Descriptor: | (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Zhao, Y, Zhang, Z. | Deposit date: | 2022-05-09 | Release date: | 2022-06-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of ligand binding modes of human EAAT2. Nat Commun, 13, 2022
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4A1O
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![BU of 4a1o by Molmil](/molmil-images/mine/4a1o) | Crystal structure of Mycobacterium tuberculosis PurH complexed with AICAR and a novel nucleotide CFAIR, at 2.48 A resolution. | Descriptor: | 5-(FORMYLAMINO)-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, ... | Authors: | Le Nours, J, Bulloch, E.M.M, Zhang, Z, Greenwood, D.R, Middleditch, M.J, Dickson, J.M.J, Baker, E.N. | Deposit date: | 2011-09-17 | Release date: | 2011-09-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural Analyses of a Purine Biosynthetic Enzyme from Mycobacterium Tuberculosis Reveal a Novel Bound Nucleotide. J.Biol.Chem., 286, 2011
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8OW1
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![BU of 8ow1 by Molmil](/molmil-images/mine/8ow1) | Cryo-EM structure of the yeast Inner kinetochore bound to a CENP-A nucleosome. | Descriptor: | C0N3, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | Authors: | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | Deposit date: | 2023-04-26 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
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4AEZ
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![BU of 4aez by Molmil](/molmil-images/mine/4aez) | Crystal Structure of Mitotic Checkpoint Complex | Descriptor: | MITOTIC SPINDLE CHECKPOINT COMPONENT MAD2, MITOTIC SPINDLE CHECKPOINT COMPONENT MAD3, WD REPEAT-CONTAINING PROTEIN SLP1 | Authors: | Kulkarni, K.A, Chao, W.C.H, Zhang, Z, Barford, D. | Deposit date: | 2012-01-13 | Release date: | 2012-03-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Mitotic Checkpoint Complex Nature, 484, 2012
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4A2N
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![BU of 4a2n by Molmil](/molmil-images/mine/4a2n) | Crystal Structure of Ma-ICMT | Descriptor: | CARDIOLIPIN, ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE, PALMITIC ACID, ... | Authors: | Yang, J, Kulkarni, K, Manolaridis, I, Zhang, Z, Dodd, R.B, Mas-Droux, C, Barford, D. | Deposit date: | 2011-09-27 | Release date: | 2012-01-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase Icmt. Mol.Cell, 44, 2011
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6B70
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![BU of 6b70 by Molmil](/molmil-images/mine/6b70) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin | Descriptor: | FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-03 | Release date: | 2017-12-27 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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3ZZM
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![BU of 3zzm by Molmil](/molmil-images/mine/3zzm) | Crystal structure of Mycobacterium tuberculosis PurH with a novel bound nucleotide CFAIR, at 2.2 A resolution. | Descriptor: | 5-(FORMYLAMINO)-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, GLYCEROL, ... | Authors: | Le Nours, J, Bulloch, E.M.M, Zhang, Z, Greenwood, D.R, Middleditch, M.J, Dickson, J.M.J, Baker, E.N. | Deposit date: | 2011-09-02 | Release date: | 2011-09-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Analyses of a Purine Biosynthetic Enzyme from Mycobacterium Tuberculosis Reveal a Novel Bound Nucleotide. J.Biol.Chem., 286, 2011
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4BH6
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![BU of 4bh6 by Molmil](/molmil-images/mine/4bh6) | Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex | Descriptor: | APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1 | Authors: | He, J, Chao, W.C.H, Zhang, Z, Yang, J, Cronin, N, Barford, D. | Deposit date: | 2013-03-29 | Release date: | 2013-06-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex. Mol.Cell, 50, 2013
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7K0N
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![BU of 7k0n by Molmil](/molmil-images/mine/7k0n) | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 2 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H. | Deposit date: | 2020-09-04 | Release date: | 2021-02-24 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the regulation of human serine palmitoyltransferase complexes. Nat.Struct.Mol.Biol., 28, 2021
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5BPT
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