6GYU
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![BU of 6gyu by Molmil](/molmil-images/mine/6gyu) | Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore | Descriptor: | Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | Authors: | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | Deposit date: | 2018-07-02 | Release date: | 2018-12-05 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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6GYS
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![BU of 6gys by Molmil](/molmil-images/mine/6gys) | Cryo-EM structure of the CBF3-CEN3 complex of the budding yeast kinetochore | Descriptor: | Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | Authors: | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | Deposit date: | 2018-07-01 | Release date: | 2018-12-05 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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6GYP
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![BU of 6gyp by Molmil](/molmil-images/mine/6gyp) | Cryo-EM structure of the CBF3-core-Ndc10-DBD complex of the budding yeast kinetochore | Descriptor: | ARGININE, ASPARAGINE, Centromere DNA-binding protein complex CBF3 subunit A, ... | Authors: | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | Deposit date: | 2018-07-01 | Release date: | 2018-12-05 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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5BK8
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![BU of 5bk8 by Molmil](/molmil-images/mine/5bk8) | Cancer-associated SHP2/T507K mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Zhang, R.Y, Zhang, Z.Y. | Deposit date: | 2019-06-01 | Release date: | 2020-04-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2. J.Biol.Chem., 295, 2020
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2FF0
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![BU of 2ff0 by Molmil](/molmil-images/mine/2ff0) | Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit Promoter | Descriptor: | CTGTGGCCCTGAGCC, GGCTCAGGGCCACAG, Steroidogenic factor 1, ... | Authors: | Little, T.H, Zhang, Y, Matulis, C.K, Weck, J, Zhang, Z, Ramachandran, A, Mayo, K.E, Radhakrishnan, I. | Deposit date: | 2005-12-17 | Release date: | 2006-04-11 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Sequence-specific deoxyribonucleic Acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability. Mol.Endocrinol., 20, 2006
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7FIR
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![BU of 7fir by Molmil](/molmil-images/mine/7fir) | The crystal structure of beta-1,2-mannobiose phosphorylase in complex with 1,4-mannobiose | Descriptor: | Beta-1,2-mannobiose phosphorylase, PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... | Authors: | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | Deposit date: | 2021-08-01 | Release date: | 2022-01-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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7FIQ
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![BU of 7fiq by Molmil](/molmil-images/mine/7fiq) | The crystal structure of mannose-bound beta-1,2-mannobiose phosphorylase from Thermoanaerobacter sp. | Descriptor: | Beta-1,2-mannobiose phosphorylase, GLYCEROL, PENTAETHYLENE GLYCOL, ... | Authors: | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | Deposit date: | 2021-08-01 | Release date: | 2022-01-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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7FIS
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![BU of 7fis by Molmil](/molmil-images/mine/7fis) | The crystal structure of beta-1,2-mannobiose phosphorylase in complex with mannose 1-phosphate (M1P) | Descriptor: | 1-O-phosphono-alpha-D-mannopyranose, Beta-1,2-mannobiose phosphorylase, GLYCEROL, ... | Authors: | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | Deposit date: | 2021-08-01 | Release date: | 2022-01-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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7U5H
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![BU of 7u5h by Molmil](/molmil-images/mine/7u5h) | Cryo-EM Structure of DNPEP | Descriptor: | Aspartyl aminopeptidase, ZINC ION | Authors: | Morgan, C.E, Yu, E.W, Zhang, Z. | Deposit date: | 2022-03-02 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Toward structural-omics of the bovine retinal pigment epithelium. Cell Rep, 41, 2022
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7U5L
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![BU of 7u5l by Molmil](/molmil-images/mine/7u5l) | Cryo-EM Structure of Ferritin | Descriptor: | FE (III) ION, Ferritin heavy chain | Authors: | Morgan, C.E, Zhang, Z, Yu, E.W. | Deposit date: | 2022-03-02 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Toward structural-omics of the bovine retinal pigment epithelium. Cell Rep, 41, 2022
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5C6H
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![BU of 5c6h by Molmil](/molmil-images/mine/5c6h) | Mcl-1 complexed with Mule | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mule BH3 peptide from E3 ubiquitin-protein ligase HUWE1 | Authors: | Song, T, Wang, Z, Ji, F, Chai, G, Liu, Y, Li, X, Li, Z, Fan, Y, Zhang, Z. | Deposit date: | 2015-06-23 | Release date: | 2016-08-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure of Mcl-1 complexed with Mule at 2.05 Angstroms resolution To Be Published
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8HKF
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![BU of 8hkf by Molmil](/molmil-images/mine/8hkf) | ion channel | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | Authors: | Jiang, D.H, Zhang, Z.T. | Deposit date: | 2022-11-25 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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5KQL
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5KQP
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![BU of 5kqp by Molmil](/molmil-images/mine/5kqp) | Crystal structure of Apo-form LMW-PTP | Descriptor: | Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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8HDZ
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![BU of 8hdz by Molmil](/molmil-images/mine/8hdz) | Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in an apo form | Descriptor: | A22 DNA replication processivity factor, E4 uracil-DNA glycosylase, F8 DNA polymerase | Authors: | Xu, Y, Wu, Y, Zhang, Y, Fan, R, Yang, Y, Li, D, Yang, B, Zhang, Z, Dong, C. | Deposit date: | 2022-11-07 | Release date: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex. Cell Res., 33, 2023
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5KQG
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5KQM
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![BU of 5kqm by Molmil](/molmil-images/mine/5kqm) | Co-crystal structure of LMW-PTP in complex with MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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6U8V
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![BU of 6u8v by Molmil](/molmil-images/mine/6u8v) | Crystal structure of DNMT3B-DNMT3L in complex with CpGpT DNA | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Zhang, Z.M, Song, J. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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6U8W
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![BU of 6u8w by Molmil](/molmil-images/mine/6u8w) | Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Zhang, Z.M, Song, J. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.94891548 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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3HH0
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![BU of 3hh0 by Molmil](/molmil-images/mine/3hh0) | Crystal structure of a transcriptional regulator, MerR family from Bacillus cereus | Descriptor: | Transcriptional regulator, MerR family | Authors: | Palani, K, Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-05-14 | Release date: | 2009-05-26 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Crystal structure of a transcriptional regulator, MerR family from Bacillus cereus To be Published
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8GS9
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![BU of 8gs9 by Molmil](/molmil-images/mine/8gs9) | SARS-CoV-2 BA.2 spike RBD in complex bound with VacBB-551 | Descriptor: | Heavy chain of VacBB-551, Light chain of VacBB-551, Spike glycoprotein | Authors: | Liu, C.C, Ju, B, Shen, S.L, Zhang, Z. | Deposit date: | 2022-09-05 | Release date: | 2023-05-03 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Omicron BQ.1.1 and XBB.1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccination. Cell Rep, 42, 2023
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8GSB
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7FIP
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![BU of 7fip by Molmil](/molmil-images/mine/7fip) | The native structure of beta-1,2-mannobiose phosphorylase from Thermoanaerobacter sp. | Descriptor: | Beta-1,2-mannobiose phosphorylase, ZINC ION | Authors: | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | Deposit date: | 2021-08-01 | Release date: | 2022-01-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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6O2P
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![BU of 6o2p by Molmil](/molmil-images/mine/6o2p) | Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR) | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, ... | Authors: | Liu, F, Zhang, Z, Chen, J, Levit, A, Shoichet, B. | Deposit date: | 2019-02-24 | Release date: | 2019-06-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural identification of a hotspot on CFTR for potentiation. Science, 364, 2019
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1PTY
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![BU of 1pty by Molmil](/molmil-images/mine/1pty) | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES | Descriptor: | MAGNESIUM ION, O-PHOSPHOTYROSINE, PROTEIN TYROSINE PHOSPHATASE 1B | Authors: | Zhao, Y, Puius, Y.A, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. | Deposit date: | 1997-01-16 | Release date: | 1998-01-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997
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