8HDZ

Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in an apo form

Summary for 8HDZ

• Entry DOI: 10.2210/pdb8hdz/pdb
• EMDB information: 34684
• Descriptor: F8 DNA polymerase, A22 DNA replication processivity factor, E4 uracil-DNA glycosylase (3 entities in total)
• Functional Keywords: dna replication machinery, f8, a22, e4, dna polymerase, b-family dna polymerase, uracil-dna glycosylase, mpxv, orthopoxvirus, poxviridae, dna processivity factor, viral protein
• Biological source: Monkeypox virus; More
• Total number of polymer chains: 3
• Total formula weight: 197128.79

Authors

Xu, Y.,Wu, Y.,Zhang, Y.,Fan, R.,Yang, Y.,Li, D.,Yang, B.,Zhang, Z.,Dong, C. (deposition date: 2022-11-07, release date: 2023-11-15, Last modification date: 2025-07-02)

• Primary citation: Xu, Y.,Wu, Y.,Zhang, Y.,Fan, R.,Yang, Y.,Li, D.,Zhu, S.,Yang, B.,Zhang, Z.,Dong, C.; Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex.; Cell Res., 33:479-482, 2023; PubMed: 36973539; DOI: 10.1038/s41422-023-00796-1

Experimental method

ELECTRON MICROSCOPY (3.05 Å)