8FBZ
| Crystal Structure of apo human Glutathione Synthetase Y270E | 分子名称: | GLYCEROL, Glutathione synthetase, SULFATE ION | 著者 | Stanford, S.M, Santelli, E, Sankaran, B, Murali, R, Bottini, N. | 登録日 | 2022-11-30 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Sci Adv, 10, 2024
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8THM
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5JNT
| Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with MES | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5JNV
| Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5JNU
| Crystal structure of mouse Low-Molecular Weight Protein Tyrosine Phosphatase type A (LMPTP-A) complexed with phosphate | 分子名称: | Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.535 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5JNS
| Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with phosphate | 分子名称: | DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5JNR
| Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A | 分子名称: | Low molecular weight phosphotyrosine protein phosphatase | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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5JNW
| Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with vanadate and uncompetitive inhibitor | 分子名称: | 2-(4-{[3-(piperidin-1-yl)propyl]amino}quinolin-2-yl)benzonitrile, Low molecular weight phosphotyrosine protein phosphatase, VANADATE ION | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | 登録日 | 2016-04-30 | 公開日 | 2017-03-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13, 2017
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7KH8
| Human LMPTP in complex with inhibitor | 分子名称: | 3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine, Low molecular weight phosphotyrosine protein phosphatase, NITRATE ION | 著者 | Stanford, S.M, Diaz, M.A, Ardecky, R.J, Zou, J, Roosild, T, Holmes, Z.J, Hedrick, M.P, Rodiles, S, Santelli, E, Chung, T.D.Y, Jackson, M.R, Bottini, N, Pinkerton, A.B. | 登録日 | 2020-10-20 | 公開日 | 2021-05-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J.Med.Chem., 64, 2021
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2GYS
| 2.7 A structure of the extracellular domains of the human beta common receptor involved in IL-3, IL-5, and GM-CSF signalling | 分子名称: | Cytokine receptor common beta chain, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Carr, P.D, Conlan, F, Ford, S, Ollis, D.L, Young, I.G. | 登録日 | 2006-05-09 | 公開日 | 2006-06-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. Acta Crystallogr.,Sect.F, 62, 2006
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3HHA
| Crystal structure of cathepsin L in complex with AZ12878478 | 分子名称: | ACETATE ION, Cathepsin L1, GLYCEROL, ... | 著者 | Asaad, N, Bethel, P.A, Coulson, M.D, Dawson, J, Ford, S.J, Gerhardt, S, Grist, M, Hamlin, G.A, James, M.J, Jones, E.V, Karoutchi, G.I, Kenny, P.W, Morley, A.D, Oldham, K, Rankine, N, Ryan, D, Wells, S.L, Wood, L, Augustin, M, Krapp, S, Simader, H, Steinbacher, S. | 登録日 | 2009-05-15 | 公開日 | 2009-06-23 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg.Med.Chem.Lett., 19, 2009
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1GH7
| CRYSTAL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE BETA-COMMON RECEPTOR OF IL-3, IL-5, AND GM-CSF | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CYTOKINE RECEPTOR COMMON BETA CHAIN, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Carr, P.D, Gustin, S.E, Church, A.P, Murphy, J.M, Ford, S.C, Mann, D.A, Woltring, D.M, Walker, I, Ollis, D.L, Young, I.G. | 登録日 | 2000-11-27 | 公開日 | 2001-11-28 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell(Cambridge,Mass.), 104, 2001
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2W07
| Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF | 分子名称: | CHAPERONE PROTEIN PAPD, MINOR PILIN SUBUNIT PAPF, SULFATE ION | 著者 | Verger, D, Rose, R.J, Paci, E, Costakes, G, Daviter, T, Hultgren, S, Remaut, H, Ashcroft, A.E, Radford, S.E, Waksman, G. | 登録日 | 2008-08-12 | 公開日 | 2008-11-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Determinants of Polymerization Reactivity of the P Pilus Adaptor Subunit Papf. Structure, 16, 2008
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1YAI
| X-RAY STRUCTURE OF A BACTERIAL COPPER,ZINC SUPEROXIDE DISMUTASE | 分子名称: | COPPER (II) ION, COPPER, ZINC SUPEROXIDE DISMUTASE, ... | 著者 | Bourne, Y, Redford, S.M, Lo, T.P, Tainer, J.A, Getzoff, E.D. | 登録日 | 1996-02-03 | 公開日 | 1997-08-20 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase. Proc.Natl.Acad.Sci.USA, 93, 1996
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5LJO
| E. coli BAM complex (BamABCDE) by cryoEM | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | 著者 | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Schffrin, B, Calabrese, A.N, Ashcroft, A.E, Brockwell, D.J. | 登録日 | 2016-07-19 | 公開日 | 2016-10-12 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Nat Commun, 7, 2016
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4DS0
| Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen | 分子名称: | Outer capsid protein VP4, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Hu, L, Crawford, S.E, Czako, R, Cortes-Penfield, N.W, Smith, D.F, Le Pendu, J, Estes, M.K, Prasad, B.V.V. | 登録日 | 2012-02-17 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature, 485, 2012
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7BM5
| Crystal structure of Fab1, the Fab fragment of the anti-BamA monoclonal antibody MAB1 | 分子名称: | Fab1 heavy chain, Fab1 light chain | 著者 | White, P, Storek, K.M, Rutherford, S.T, Radford, S.E. | 登録日 | 2021-01-19 | 公開日 | 2021-06-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding. Nat Commun, 12, 2021
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8OH2
| Structure of the Tau-PAM4 Type 1 amyloid fibril | 分子名称: | Microtubule-associated protein tau | 著者 | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | 登録日 | 2023-03-20 | 公開日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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8OHP
| Structure of the Fmoc-Tau-PAM4 Type 3 amyloid fibril | 分子名称: | Microtubule-associated protein tau | 著者 | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | 登録日 | 2023-03-21 | 公開日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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8OI0
| Structure of the Fmoc-Tau-PAM4 Type 4 amyloid fibril | 分子名称: | Microtubule-associated protein tau | 著者 | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | 登録日 | 2023-03-21 | 公開日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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6XOD
| Crystal structure of the PEX4-PEX22 protein complex from Arabidopsis thaliana | 分子名称: | Peroxisome biogenesis protein 22, Protein PEROXIN-4 | 著者 | Olmos Jr, J.L, Bradford, S.E, Miller, M.D, Xu, W, Wright, Z.J, Bartel, B, Phillips Jr, G.N. | 登録日 | 2020-07-06 | 公開日 | 2021-07-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex-Insights Into Ubiquitination at the Peroxisomal Membrane Front Cell Dev Biol, 10, 2022
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8QPZ
| CryoEM structure of recombinant DeltaN7 alpha-synuclein in PBS | 分子名称: | Alpha-synuclein | 著者 | Thacker, D, Wilkinson, M, Dewison, K.M, Ranson, N.A, Brockwell, D.J, Radford, S.E. | 登録日 | 2023-10-03 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Residues 2 to 7 of alpha-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways. Proc.Natl.Acad.Sci.USA, 121, 2024
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8OHI
| Structure of the Fmoc-Tau-PAM4 Type 2 amyloid fibril | 分子名称: | Microtubule-associated protein tau | 著者 | Wilkinson, M, Louros, N, Tsaka, G, Ramakers, M, Morelli, C, Garcia, T, Gallardo, R.U, D'Haeyer, S, Goossens, V, Audenaert, D, Thal, D.R, Ranson, N.A, Radford, S.E, Rousseau, F, Schymkowitz, J. | 登録日 | 2023-03-21 | 公開日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15, 2024
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8BFB
| Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice) | 分子名称: | Amyloid-beta precursor protein | 著者 | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | 登録日 | 2022-10-24 | 公開日 | 2023-05-31 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14, 2023
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8BFA
| Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure | 分子名称: | Amyloid-beta precursor protein | 著者 | Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W. | 登録日 | 2022-10-24 | 公開日 | 2023-05-31 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14, 2023
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