5JNU

Crystal structure of mouse Low-Molecular Weight Protein Tyrosine Phosphatase type A (LMPTP-A) complexed with phosphate

Summary for 5JNU

Related5JNR 5JNS 5JNT 5JNV 5JNW
DescriptorLow molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION (3 entities in total)
Functional Keywordsprotein tyrosine phosphatase, hydrolase, lmw-ptp, lmptp
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm  Q9D358
Total number of polymer chains2
Total molecular weight36814.72
Authors
Stanford, S.M.,Aleshin, A.E.,Liddington, R.C.,Bankston, L.,Cadwell, G.,Bottini, N. (deposition date: 2016-04-30, release date: 2017-03-29, Last modification date: 2017-09-20)
Primary citation
Stanford, S.M.,Aleshin, A.E.,Zhang, V.,Ardecky, R.J.,Hedrick, M.P.,Zou, J.,Ganji, S.R.,Bliss, M.R.,Yamamoto, F.,Bobkov, A.A.,Kiselar, J.,Liu, Y.,Cadwell, G.W.,Khare, S.,Yu, J.,Barquilla, A.,Chung, T.D.Y.,Mustelin, T.,Schenk, S.,Bankston, L.A.,Liddington, R.C.,Pinkerton, A.B.,Bottini, N.
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13:624-632, 2017
PubMed: 28346406 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.2344
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.535 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.248201.4%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report