5JNV

Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES

Summary for 5JNV

Entry DOI	10.2210/pdb5jnv/pdb
Related	5JNR 5JNS 5JNT 5JNU 5JNW
Descriptor	Low molecular weight phosphotyrosine protein phosphatase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	protein tyrosine phosphatase, hydrolase, lmw-ptp, lmptp
Biological source	Bos taurus (Bovine)
Total number of polymer chains	1
Total formula weight	18555.14
Authors	Stanford, S.M.,Aleshin, A.E.,Liddington, R.C.,Bankston, L.,Cadwell, G.,Bottini, N. (deposition date: 2016-04-30, release date: 2017-03-29, Last modification date: 2023-09-27)
Primary citation	Stanford, S.M.,Aleshin, A.E.,Zhang, V.,Ardecky, R.J.,Hedrick, M.P.,Zou, J.,Ganji, S.R.,Bliss, M.R.,Yamamoto, F.,Bobkov, A.A.,Kiselar, J.,Liu, Y.,Cadwell, G.W.,Khare, S.,Yu, J.,Barquilla, A.,Chung, T.D.Y.,Mustelin, T.,Schenk, S.,Bankston, L.A.,Liddington, R.C.,Pinkerton, A.B.,Bottini, N. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat. Chem. Biol., 13:624-632, 2017 Cited by PubMed: 28346406 DOI: 10.1038/nchembio.2344 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation