3HHA

Crystal structure of cathepsin L in complex with AZ12878478

Summary for 3HHA

Entry DOI	10.2210/pdb3hha/pdb
Descriptor	Cathepsin L1, Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2Z)-2-iminoethyl]-3-methyl-L-phenylalaninamide, TETRAETHYLENE GLYCOL, ... (7 entities in total)
Functional Keywords	proteros biostructures gmbh, cathepsin l, inhibitors, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P07711
Total number of polymer chains	4
Total formula weight	98676.19
Authors	Asaad, N.,Bethel, P.A.,Coulson, M.D.,Dawson, J.,Ford, S.J.,Gerhardt, S.,Grist, M.,Hamlin, G.A.,James, M.J.,Jones, E.V.,Karoutchi, G.I.,Kenny, P.W.,Morley, A.D.,Oldham, K.,Rankine, N.,Ryan, D.,Wells, S.L.,Wood, L.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S. (deposition date: 2009-05-15, release date: 2009-06-23, Last modification date: 2021-10-13)
Primary citation	Asaad, N.,Bethel, P.A.,Coulson, M.D.,Dawson, J.E.,Ford, S.J.,Gerhardt, S.,Grist, M.,Hamlin, G.A.,James, M.J.,Jones, E.V.,Karoutchi, G.I.,Kenny, P.W.,Morley, A.D.,Oldham, K.,Rankine, N.,Ryan, D.,Wells, S.L.,Wood, L.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S. Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg.Med.Chem.Lett., 19:4280-4283, 2009 Cited by PubMed: 19515558 DOI: 10.1016/j.bmcl.2009.05.071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.27 Å)

Structure validation