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3HHA

Crystal structure of cathepsin L in complex with AZ12878478

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0006508biological_processproteolysis
B0008234molecular_functioncysteine-type peptidase activity
C0006508biological_processproteolysis
C0008234molecular_functioncysteine-type peptidase activity
D0006508biological_processproteolysis
D0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE NOW A 301
ChainResidue
AGLN19
AMET70
AALA135
AMET161
AASP162
APG4221
AACT222
AHOH746
AGLY23
ASER24
ACYS25
ATRP26
AGLY61
AGLY67
AGLY68
ALEU69

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PG4 A 221
ChainResidue
AGLN19
AGLY20
AGLN21
ACYS22
AGLY23
ATRP189
AACT222
ANOW301
AHOH447
CGLU141

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 222
ChainResidue
AASN66
AASP162
APG4221
ANOW301
AHOH994

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE NOW B 301
ChainResidue
BGLN19
BGLY23
BSER24
BCYS25
BTRP26
BGLY61
BGLU63
BGLY67
BGLY68
BLEU69
BALA135
BMET161
BASP162
BPGE221
BHOH613
BHOH952
BHOH956

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PGE B 221
ChainResidue
BGLN19
BGLY20
BCYS22
BGLY23
BLEU144
BTRP189
BNOW301
BHOH440
BHOH882

site_idAC6
Number of Residues13
DetailsBINDING SITE FOR RESIDUE NOW C 301
ChainResidue
CGLN19
CGLY23
CSER24
CCYS25
CTRP26
CGLY61
CGLY67
CGLY68
CLEU69
CALA135
CMET161
CASP162
CHOH988

site_idAC7
Number of Residues13
DetailsBINDING SITE FOR RESIDUE NOW D 301
ChainResidue
DGLN19
DGLY23
DSER24
DCYS25
DTRP26
DGLY61
DGLY67
DGLY68
DLEU69
DALA135
DMET161
DASP162
DHOH989

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL D 221
ChainResidue
DLYS17
DASN18
DGLU86

Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA
ChainResidueDetails
AGLN19-ALA30

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG
ChainResidueDetails
AMET161-GLY171

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM
ChainResidueDetails
ATYR182-MET201

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsPropeptide: {"featureId":"PRO_0000026246"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsActive site: {}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues44
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HFV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
AASN187
ACYS25
AHIS163

site_idCSA10
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
BASN187
BGLN19
BHIS163

site_idCSA11
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
CASN187
CGLN19
CHIS163

site_idCSA12
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
DASN187
DGLN19
DHIS163

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
BASN187
BCYS25
BHIS163

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
CASN187
CCYS25
CHIS163

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
DASN187
DCYS25
DHIS163

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
AGLN19
ACYS25
AHIS163

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
BGLN19
BCYS25
BHIS163

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
CGLN19
CCYS25
CHIS163

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
DGLN19
DCYS25
DHIS163

site_idCSA9
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
AASN187
AGLN19
AHIS163

239149

PDB entries from 2025-07-23

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