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3HHA

Crystal structure of cathepsin L in complex with AZ12878478

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Cathepsin L1polymer22024161.74UniProt (P07711)
Pfam (PF00112)
Homo sapiens (human)Major excreted protein, MEP, Cathepsin L1 heavy chain, Cathepsin L1 light chain
2E, H, J, K
(A, B, C, D)
Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2Z)-2-iminoethyl]-3-methyl-L-phenylalaninamidenon-polymer383.54Chemie (NOW)
3F
(A)
TETRAETHYLENE GLYCOLnon-polymer194.21Chemie (PG4)
4G
(A)
ACETATE IONnon-polymer59.01Chemie (ACT)
5I
(B)
TRIETHYLENE GLYCOLnon-polymer150.21Chemie (PGE)
6L
(D)
GLYCEROLnon-polymer92.11Chemie (GOL)
7M, N, O, P
(A, B, C, D)
waterwater18.0993Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
PDBExternal DatabaseDetails
Ala 110Thr 223engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight96646.7
Non-Polymers*Number of molecules8
Total formula weight2029.5
All*Total formula weight98676.2
*Water molecules are not included.

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PDB entries from 2025-07-23

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