3HHA
Crystal structure of cathepsin L in complex with AZ12878478
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cathepsin L1 | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (human) | Major excreted protein, MEP, Cathepsin L1 heavy chain, Cathepsin L1 light chain |
| 2 | E, H, J, K (A, B, C, D) | Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2Z)-2-iminoethyl]-3-methyl-L-phenylalaninamide | non-polymer | 383.5 | 4 | Chemie (NOW) | |||
| 3 | F (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | G (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | I (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 6 | L (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 993 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96646.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2029.5 | |
| All* | Total formula weight | 98676.2 |
