2TRM
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2IST
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2G8X
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![BU of 2g8x by Molmil](/molmil-images/mine/2g8x) | Escherichia coli Y209W apoprotein | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CARBONATE ION, PHOSPHATE ION, ... | Authors: | Lee, T.T, Finer-Moore, J.S, Stroud, R.M. | Deposit date: | 2006-03-03 | Release date: | 2006-03-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261 TO BE PUBLISHED
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2BE1
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![BU of 2be1 by Molmil](/molmil-images/mine/2be1) | Structure of the compact lumenal domain of yeast Ire1 | Descriptor: | Serine/threonine-protein kinase/endoribonuclease IRE1, peptide | Authors: | Credle, J.J, Finer-Moore, J.S, Papa, F.R, Stroud, R.M, Walter, P. | Deposit date: | 2005-10-21 | Release date: | 2005-12-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.983 Å) | Cite: | Inaugural Article: On the mechanism of sensing unfolded protein in the endoplasmic reticulum Proc.Natl.Acad.Sci.Usa, 102, 2005
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8SBE
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![BU of 8sbe by Molmil](/molmil-images/mine/8sbe) | Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM | Descriptor: | Vesicular glutamate transporter 2 | Authors: | Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R. | Deposit date: | 2023-04-03 | Release date: | 2023-05-03 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ion transport and regulation in a synaptic vesicle glutamate transporter. Science, 368, 2020
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2BBQ
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![BU of 2bbq by Molmil](/molmil-images/mine/2bbq) | STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE | Descriptor: | 10-PARPARGYL-5,8-DIDEAZAFOLATE-4-GLUTAMIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | Authors: | Kamb, A, Finer-Moore, J, Stroud, R.M. | Deposit date: | 1992-09-16 | Release date: | 1994-01-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for recognition of polyglutamyl folates by thymidylate synthase. Biochemistry, 31, 1992
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7UK4
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![BU of 7uk4 by Molmil](/molmil-images/mine/7uk4) | KS-AT di-domain of mycobacterial Pks13 with endogenous KS ligand bound | Descriptor: | Polyketide synthase PKS13, UNKNOWN LIGAND | Authors: | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | Deposit date: | 2022-03-31 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (1.94 Å) | Cite: | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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3BT7
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3FBV
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![BU of 3fbv by Molmil](/molmil-images/mine/3fbv) | Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1 | Descriptor: | N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, Serine/threonine-protein kinase/endoribonuclease IRE1 | Authors: | Korennykh, A.V, Egea, P.F, Korostelev, A.A, Finer-Moore, J, Zhang, C, Shokat, K.M, Stroud, R.M, Walter, P. | Deposit date: | 2008-11-19 | Release date: | 2008-12-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The unfolded protein response signals through high-order assembly of Ire1. Nature, 457, 2009
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8CUY
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![BU of 8cuy by Molmil](/molmil-images/mine/8cuy) | ACP1-KS-AT domains of mycobacterial Pks13 | Descriptor: | 4'-PHOSPHOPANTETHEINE, Polyketide synthase PKS13, UNKNOWN LIGAND | Authors: | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | Deposit date: | 2022-05-17 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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8CV0
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![BU of 8cv0 by Molmil](/molmil-images/mine/8cv0) | KS-AT domains of mycobacterial Pks13 with outward AT conformation | Descriptor: | Polyketide synthase PKS13, UNKNOWN LIGAND | Authors: | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | Deposit date: | 2022-05-17 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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8CUZ
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![BU of 8cuz by Molmil](/molmil-images/mine/8cuz) | KS-AT domains of mycobacterial Pks13 with inward AT conformation | Descriptor: | Polyketide synthase PKS13, UNKNOWN LIGAND | Authors: | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | Deposit date: | 2022-05-17 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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8CV1
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![BU of 8cv1 by Molmil](/molmil-images/mine/8cv1) | ACP1-KS-AT domains of mycobacterial Pks13 | Descriptor: | Polyketide synthase PKS13, UNKNOWN LIGAND | Authors: | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | Deposit date: | 2022-05-17 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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3NE2
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3NK5
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![BU of 3nk5 by Molmil](/molmil-images/mine/3nk5) | Crystal structure of AqpZ mutant F43W | Descriptor: | Aquaporin Z, octyl beta-D-glucopyranoside | Authors: | Savage, D.F, O'Connell, J.D, Stroud, R.M, Finer-Moore, J.S. | Deposit date: | 2010-06-18 | Release date: | 2010-08-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural context shapes the aquaporin selectivity filter. Proc.Natl.Acad.Sci.USA, 107, 2010
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4E28
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![BU of 4e28 by Molmil](/molmil-images/mine/4e28) | Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor | Descriptor: | 2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, SULFATE ION, ... | Authors: | Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P. | Deposit date: | 2012-03-07 | Release date: | 2012-11-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J.Med.Chem., 55, 2012
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4FGT
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![BU of 4fgt by Molmil](/molmil-images/mine/4fgt) | Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme. | Descriptor: | CG peptide, SULFATE ION, Thymidylate synthase | Authors: | Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P. | Deposit date: | 2012-06-04 | Release date: | 2013-03-06 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides. J.Med.Chem., 58, 2015
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4J6E
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![BU of 4j6e by Molmil](/molmil-images/mine/4j6e) | Structure of LPXI D225A Mutant | Descriptor: | (2R,3R,4R,5S,6R)-2-{[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)-3-{[(3R)-3-hydroxytetradecanoyl]amino}tetrahydro-2H-pyran-4-yl (3R)-3-hydroxytetradecanoate, UDP-2,3-diacylglucosamine pyrophosphatase LpxI | Authors: | Metzger IV, L.E, Lee, J.K, Finer-Moore, J.S, Raetz, C.R.H, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP) | Deposit date: | 2013-02-11 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | LpxI structures reveal how a lipid A precursor is synthesized. Nat.Struct.Mol.Biol., 19, 2012
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4ITS
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![BU of 4its by Molmil](/molmil-images/mine/4its) | Crystal structure of the catalytic domain of human Pus1 with MES in the active site | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, tRNA pseudouridine synthase A, ... | Authors: | Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. | Deposit date: | 2013-01-18 | Release date: | 2013-06-05 | Last modified: | 2013-10-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. J.Mol.Biol., 425, 2013
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4IQM
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![BU of 4iqm by Molmil](/molmil-images/mine/4iqm) | Crystal structure of the catalytic domain of human Pus1 | Descriptor: | tRNA pseudouridine synthase A, mitochondrial | Authors: | Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. | Deposit date: | 2013-01-11 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. J.Mol.Biol., 425, 2013
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2OML
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![BU of 2oml by Molmil](/molmil-images/mine/2oml) | crystal structure of E. coli pseudouridine synthase RluE | Descriptor: | Ribosomal large subunit pseudouridine synthase E, SULFATE ION | Authors: | Pan, H, Ho, J.D, Stroud, R.M, Finer-Moore, J. | Deposit date: | 2007-01-22 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE. J.Mol.Biol., 367, 2007
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2OLW
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![BU of 2olw by Molmil](/molmil-images/mine/2olw) | Crystal Structure of E. coli pseudouridine synthase RluE | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETIC ACID, Ribosomal large subunit pseudouridine synthase E, ... | Authors: | Pan, H, Ho, J.D, Stroud, R.M, Finer-Moore, J. | Deposit date: | 2007-01-19 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE. J.Mol.Biol., 367, 2007
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4J37
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![BU of 4j37 by Molmil](/molmil-images/mine/4j37) | Crystal structure of the catalytic domain of human Pus1 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | Authors: | Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. | Deposit date: | 2013-02-05 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. J.Mol.Biol., 425, 2013
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1NCE
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![BU of 1nce by Molmil](/molmil-images/mine/1nce) | Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717 | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | Authors: | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2002-12-05 | Release date: | 2002-12-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The only active mutant of thymidylate synthase D169, a residue far from the
site of methyl transfer, demonstrates the exquisite nature of enzyme
specificity. Protein Eng., 16, 2003
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3SDM
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![BU of 3sdm by Molmil](/molmil-images/mine/3sdm) | Structure of oligomeric kinase/RNase Ire1 in complex with an oligonucleotide | Descriptor: | Serine/threonine-protein kinase/endoribonuclease IRE1 | Authors: | Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P. | Deposit date: | 2011-06-09 | Release date: | 2011-07-13 | Method: | X-RAY DIFFRACTION (6.6 Å) | Cite: | Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. Bmc Biol., 9, 2011
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