1NCE
Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717
Summary for 1NCE
Entry DOI | 10.2210/pdb1nce/pdb |
Related | 1bjg 1dna 1kce |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total) |
Functional Keywords | beta-sheet interface, protein-dump-cofactor analog complex, asymmetric dimer, biosynthetic protein |
Biological source | Escherichia coli, Escherichia coli O157:H7 (,) |
Cellular location | Cytoplasm : P0A884 |
Total number of polymer chains | 2 |
Total formula weight | 62666.74 |
Authors | Birdsall, D.L.,Finer-Moore, J.,Stroud, R.M. (deposition date: 2002-12-05, release date: 2002-12-25, Last modification date: 2023-08-16) |
Primary citation | Birdsall, D.L.,Finer-Moore, J.,Stroud, R.M. The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. Protein Eng., 16:229-240, 2003 Cited by PubMed: 12702803DOI: 10.1093/proeng/gzg020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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