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4GEV

E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog

Replaces:  2G8M
Summary for 4GEV
Entry DOI10.2210/pdb4gev/pdb
Related2G86 2G89 2G8A 2G8D 2G8O 2G8X
DescriptorThymidylate synthase, 2'-deoxy-5'-uridylic acid, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
Functional Keywordsbeta sheet, alpha/beta protein, methylase, transferase
Biological sourceEscherichia coli
Cellular locationCytoplasm : P0A884
Total number of polymer chains2
Total formula weight62740.73
Authors
Newby, Z.,Lee, T.T.,Finer-Moore, J.,Stroud, R.M. (deposition date: 2012-08-02, release date: 2012-08-29, Last modification date: 2017-11-15)
Primary citationWang, Z.,Abeysinghe, T.,Finer-Moore, J.S.,Stroud, R.M.,Kohen, A.
A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.
J.Am.Chem.Soc., 134:17722-17730, 2012
Cited by
PubMed: 23034004
DOI: 10.1021/ja307859m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

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