4GEV
E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog
Replaces: 2G8MSummary for 4GEV
Entry DOI | 10.2210/pdb4gev/pdb |
Related | 2G86 2G89 2G8A 2G8D 2G8O 2G8X |
Descriptor | Thymidylate synthase, 2'-deoxy-5'-uridylic acid, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total) |
Functional Keywords | beta sheet, alpha/beta protein, methylase, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm : P0A884 |
Total number of polymer chains | 2 |
Total formula weight | 62740.73 |
Authors | Newby, Z.,Lee, T.T.,Finer-Moore, J.,Stroud, R.M. (deposition date: 2012-08-02, release date: 2012-08-29, Last modification date: 2017-11-15) |
Primary citation | Wang, Z.,Abeysinghe, T.,Finer-Moore, J.S.,Stroud, R.M.,Kohen, A. A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J.Am.Chem.Soc., 134:17722-17730, 2012 Cited by PubMed: 23034004DOI: 10.1021/ja307859m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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