4GEV
E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog
Replaces: 2G8MFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0006417 | biological_process | regulation of translation |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0009314 | biological_process | response to radiation |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003723 | molecular_function | RNA binding |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0006417 | biological_process | regulation of translation |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0009314 | biological_process | response to radiation |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE UMC A 701 |
Chain | Residue |
A | ARG21 |
A | HIS207 |
A | TRP209 |
A | CB3702 |
A | HOH820 |
A | HOH859 |
B | ARG126 |
B | ARG127 |
A | CYS146 |
A | HIS147 |
A | GLN165 |
A | ARG166 |
A | SER167 |
A | CYS168 |
A | ASP169 |
A | ASN177 |
site_id | AC2 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE CB3 A 702 |
Chain | Residue |
A | GLU58 |
A | ILE79 |
A | TRP80 |
A | TRP83 |
A | LEU143 |
A | ASP169 |
A | GLY173 |
A | PHE176 |
A | ASN177 |
A | VAL262 |
A | ALA263 |
A | UMC701 |
A | HOH814 |
A | HOH831 |
A | HOH854 |
A | HOH861 |
A | HOH864 |
A | HOH880 |
A | HOH925 |
A | HOH941 |
A | HOH957 |
A | HOH1145 |
A | HOH1183 |
site_id | AC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE UMC B 801 |
Chain | Residue |
A | ARG126 |
A | ARG127 |
B | ARG21 |
B | CYS146 |
B | HIS147 |
B | GLN165 |
B | ARG166 |
B | SER167 |
B | CYS168 |
B | ASP169 |
B | ASN177 |
B | HIS207 |
B | TRP209 |
B | CB3802 |
B | HOH911 |
B | HOH915 |
site_id | AC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE CB3 B 802 |
Chain | Residue |
B | GLU58 |
B | ILE79 |
B | TRP80 |
B | TRP83 |
B | ASP169 |
B | GLY173 |
B | PHE176 |
B | ASN177 |
B | VAL262 |
B | ALA263 |
B | UMC801 |
B | HOH922 |
B | HOH931 |
B | HOH961 |
B | HOH963 |
B | HOH967 |
B | HOH969 |
B | HOH992 |
B | HOH1025 |
B | HOH1110 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIvsaWNvgeldkma.....LaPCHaffQFyV |
Chain | Residue | Details |
A | ARG126-VAL154 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0000269|PubMed:9416600 |
Chain | Residue | Details |
B | CYS146 | |
A | CYS146 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
B | ARG21 | |
B | ARG166 | |
B | ASN177 | |
B | HIS207 | |
A | ARG21 | |
A | ARG166 | |
A | ASN177 | |
A | HIS207 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS |
Chain | Residue | Details |
A | ALA263 | |
B | HIS51 | |
B | ASP169 | |
B | ALA263 | |
A | HIS51 | |
A | ASP169 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
A | ARG126 | |
B | ARG126 |