4GEV

E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog

Replaces:  2G8M

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Thymidylate synthase	polymer	264	30582.7	2	UniProt (P0A884) Pfam (PF00303) In PDB	Escherichia coli	TS, TSase
2	A, B	2'-deoxy-5'-uridylic acid	non-polymer		310.2	2	Chemie (UMC)
3	A, B	10-PROPARGYL-5,8-DIDEAZAFOLIC ACID	non-polymer		477.5	2	Chemie (CB3)
4		water	water		18.0	673	Chemie (HOH)

Sequence modifications

A, B: 1 - 264 (UniProt: P0A884)

PDB	External Database	Details
Trp 209	Tyr 209	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61165.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1575.3
All*	Total formula weight	62740.7

*Water molecules are not included.