6NNR

high-resolution structure of wild-type E. coli thymidylate synthase

Replaces:  4KNZReplaces:  2G8OReplaces:  4IW5

Summary for 6NNR

• Entry DOI: 10.2210/pdb6nnr/pdb
• Descriptor: Thymidylate synthase, 2'-deoxy-5'-uridylic acid, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
• Functional Keywords: nucleotide synthesis, hydride transfer, methyl transfer, cancer drug target, transferase
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 2
• Total formula weight: 63194.27

Authors

Stroud, R.M.,Finer-Moore, J. (deposition date: 2019-01-15, release date: 2019-01-30, Last modification date: 2023-10-11)

• Primary citation: Wang, Z.,Sapienza, P.J.,Abeysinghe, T.,Luzum, C.,Lee, A.L.,Finer-Moore, J.S.,Stroud, R.M.,Kohen, A.; Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.; J. Am. Chem. Soc., 135:7583-7592, 2013; PubMed: 23611499; DOI: 10.1021/ja400761x

Experimental method

X-RAY DIFFRACTION (1.05 Å)