6NNR

high-resolution structure of wild-type E. coli thymidylate synthase

Replaces:  4KNZReplaces:  2G8OReplaces:  4IW5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Thymidylate synthase	polymer	264	30559.7	2	UniProt (P0A884) Pfam (PF00303)	Escherichia coli (strain K12)	TSase
2	C, H (A, B)	2'-deoxy-5'-uridylic acid	non-polymer		310.2	2	Chemie (UMC)
3	D, I (A, B)	10-PROPARGYL-5,8-DIDEAZAFOLIC ACID	non-polymer		477.5	2	Chemie (CB3)
4	E (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	F, G (A)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
6	J, K (A, B)	water	water		18.0	753	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61119.3
Non-Polymers*	Number of molecules	7
	Total formula weight	2074.9
All*	Total formula weight	63194.3

*Water molecules are not included.