2G8X
| Escherichia coli Y209W apoprotein | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CARBONATE ION, PHOSPHATE ION, ... | 著者 | Lee, T.T, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 2006-03-03 | 公開日 | 2006-03-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261 TO BE PUBLISHED
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1EXQ
| CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC CORE DOMAIN | 分子名称: | CADMIUM ION, CHLORIDE ION, POL POLYPROTEIN, ... | 著者 | Chen, J.C.-H, Krucinski, J, Miercke, L.J.W, Finer-Moore, J.S, Tang, A.H, Leavitt, A.D, Stroud, R.M. | 登録日 | 2000-05-03 | 公開日 | 2000-11-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc.Natl.Acad.Sci.USA, 97, 2000
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1EX4
| HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN | 分子名称: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, INTEGRASE | 著者 | Chen, J.C.-H, Krucinski, J, Miercke, L.J.W, Finer-Moore, J.S, Tang, A.H, Leavitt, A.D, Stroud, R.M. | 登録日 | 2000-04-28 | 公開日 | 2000-06-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc.Natl.Acad.Sci.USA, 97, 2000
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2GCY
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3BT7
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8CUY
| ACP1-KS-AT domains of mycobacterial Pks13 | 分子名称: | 4'-PHOSPHOPANTETHEINE, Polyketide synthase PKS13, UNKNOWN LIGAND | 著者 | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | 登録日 | 2022-05-17 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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8CV0
| KS-AT domains of mycobacterial Pks13 with outward AT conformation | 分子名称: | Polyketide synthase PKS13, UNKNOWN LIGAND | 著者 | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | 登録日 | 2022-05-17 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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8CUZ
| KS-AT domains of mycobacterial Pks13 with inward AT conformation | 分子名称: | Polyketide synthase PKS13, UNKNOWN LIGAND | 著者 | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | 登録日 | 2022-05-17 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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8CV1
| ACP1-KS-AT domains of mycobacterial Pks13 | 分子名称: | Polyketide synthase PKS13, UNKNOWN LIGAND | 著者 | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | 登録日 | 2022-05-17 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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2IST
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6C9W
| Crystal Structure of a ligand bound LacY/Nanobody Complex | 分子名称: | 4-nitrophenyl alpha-D-galactopyranoside, Lactose permease, Nanobody9047, ... | 著者 | Kumar, H, Finer-Moore, J.S, Jiang, X, Smirnova, I, Kasho, V, Pardon, E, Steyaert, J, Kaback, H.R, Stroud, R.M. | 登録日 | 2018-01-29 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structure of a ligand-bound LacY-Nanobody Complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2BE1
| Structure of the compact lumenal domain of yeast Ire1 | 分子名称: | Serine/threonine-protein kinase/endoribonuclease IRE1, peptide | 著者 | Credle, J.J, Finer-Moore, J.S, Papa, F.R, Stroud, R.M, Walter, P. | 登録日 | 2005-10-21 | 公開日 | 2005-12-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.983 Å) | 主引用文献 | Inaugural Article: On the mechanism of sensing unfolded protein in the endoplasmic reticulum Proc.Natl.Acad.Sci.Usa, 102, 2005
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2OML
| crystal structure of E. coli pseudouridine synthase RluE | 分子名称: | Ribosomal large subunit pseudouridine synthase E, SULFATE ION | 著者 | Pan, H, Ho, J.D, Stroud, R.M, Finer-Moore, J. | 登録日 | 2007-01-22 | 公開日 | 2007-03-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE. J.Mol.Biol., 367, 2007
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2OLW
| Crystal Structure of E. coli pseudouridine synthase RluE | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETIC ACID, Ribosomal large subunit pseudouridine synthase E, ... | 著者 | Pan, H, Ho, J.D, Stroud, R.M, Finer-Moore, J. | 登録日 | 2007-01-19 | 公開日 | 2007-03-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE. J.Mol.Biol., 367, 2007
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4E28
| Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor | 分子名称: | 2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, SULFATE ION, ... | 著者 | Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P. | 登録日 | 2012-03-07 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J.Med.Chem., 55, 2012
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4FGT
| Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme. | 分子名称: | CG peptide, SULFATE ION, Thymidylate synthase | 著者 | Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P. | 登録日 | 2012-06-04 | 公開日 | 2013-03-06 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides. J.Med.Chem., 58, 2015
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3NK5
| Crystal structure of AqpZ mutant F43W | 分子名称: | Aquaporin Z, octyl beta-D-glucopyranoside | 著者 | Savage, D.F, O'Connell, J.D, Stroud, R.M, Finer-Moore, J.S. | 登録日 | 2010-06-18 | 公開日 | 2010-08-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural context shapes the aquaporin selectivity filter. Proc.Natl.Acad.Sci.USA, 107, 2010
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1NCE
| Crystal structure of a ternary complex of E. coli thymidylate synthase D169C with dUMP and the antifolate CB3717 | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | 著者 | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | 登録日 | 2002-12-05 | 公開日 | 2002-12-25 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The only active mutant of thymidylate synthase D169, a residue far from the
site of methyl transfer, demonstrates the exquisite nature of enzyme
specificity. Protein Eng., 16, 2003
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3R1F
| Crystal structure of a key regulator of virulence in Mycobacterium tuberculosis | 分子名称: | ESX-1 secretion-associated regulator EspR | 著者 | Rosenberg, O.S, Dovey, C, Finer-Moore, J, Stroud, R.M, Cox, J.S. | 登録日 | 2011-03-10 | 公開日 | 2011-08-03 | 最終更新日 | 2011-08-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc.Natl.Acad.Sci.USA, 108, 2011
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2TRM
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4ISK
| Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2'-deoxy-5'-uridylic acid, MAGNESIUM ION, ... | 著者 | Tochowicz, A, Finer-Moore, J, Stroud, R.M. | 登録日 | 2013-01-16 | 公開日 | 2013-12-25 | 最終更新日 | 2014-02-12 | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | 主引用文献 | Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells. J.Med.Chem., 56, 2013
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4ITS
| Crystal structure of the catalytic domain of human Pus1 with MES in the active site | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, tRNA pseudouridine synthase A, ... | 著者 | Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 2013-01-18 | 公開日 | 2013-06-05 | 最終更新日 | 2013-10-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. J.Mol.Biol., 425, 2013
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4IQM
| Crystal structure of the catalytic domain of human Pus1 | 分子名称: | tRNA pseudouridine synthase A, mitochondrial | 著者 | Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 2013-01-11 | 公開日 | 2013-06-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. J.Mol.Biol., 425, 2013
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3NKA
| Crystal structure of AqpZ H174G,T183F | 分子名称: | Aquaporin Z, GLYCEROL, octyl beta-D-glucopyranoside | 著者 | Savage, D.F, O'Connell III, J.D, Finer-Moore, J, Stroud, R.M. | 登録日 | 2010-06-18 | 公開日 | 2010-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural context shapes the aquaporin selectivity filter. Proc.Natl.Acad.Sci.USA, 107, 2010
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4J37
| Crystal structure of the catalytic domain of human Pus1 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | 著者 | Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 2013-02-05 | 公開日 | 2013-06-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. J.Mol.Biol., 425, 2013
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