4ITS
Crystal structure of the catalytic domain of human Pus1 with MES in the active site
Summary for 4ITS
Entry DOI | 10.2210/pdb4its/pdb |
Related | 4IQM 4J37 |
Descriptor | tRNA pseudouridine synthase A, mitochondrial, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (4 entities in total) |
Functional Keywords | beta sheet, isomerase, pseudouridine synthase, rna binding protein, rna modification, trna, pre-trna, steroid receptor rna activator, u2 snrna |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Mitochondrion. Isoform 2: Nucleus: Q9Y606 |
Total number of polymer chains | 1 |
Total formula weight | 38529.85 |
Authors | Czudnochowski, N.,Finer-Moore, J.S.,Stroud, R.M. (deposition date: 2013-01-18, release date: 2013-06-05, Last modification date: 2013-10-23) |
Primary citation | Czudnochowski, N.,Wang, A.L.,Finer-Moore, J.,Stroud, R.M. In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. J.Mol.Biol., 425:3875-3887, 2013 Cited by PubMed: 23707380DOI: 10.1016/j.jmb.2013.05.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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