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PDB: 173 results

6V8T
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Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with LSZ102
Descriptor: Estrogen receptor, LSZ102
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2019-12-12
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
Elife, 11, 2022
5DXB
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Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol
Descriptor: CHLORIDE ION, ESTRADIOL, Estrogen receptor, ...
Authors:Fanning, S.W, Speltz, T.E, Mayne, C.G, Tajkhorshid, E, Greene, G.L, Moore, T.W.
Deposit date:2015-09-23
Release date:2016-07-27
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
Angew. Chem. Int. Ed. Engl., 55, 2016
6VPF
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Estrogen Receptor Alpha Ligand Binding Domain in Complex with the Selective Estrogen Receptor Modulator Clomiphene
Descriptor: Clomifene, Estrogen receptor
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2020-02-03
Release date:2020-09-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
Elife, 11, 2022
3QXW
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Free structure of an anti-methotrexate CDR1-4 Graft VHH Antibody
Descriptor: Anti-Methotrexate CDR1-4 Graft VHH, SODIUM ION, SULFATE ION
Authors:Fanning, S.W, Horn, J.R.
Deposit date:2011-03-02
Release date:2011-07-27
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop.
Protein Sci., 20, 2011
4POY
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Engineered Dual Specific VHH antibody
Descriptor: VHH-metal
Authors:Fanning, S.W, Walter, R, Horn, J.R.
Deposit date:2014-02-26
Release date:2014-09-24
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
4POU
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VHH-metal in Complex with RNase A
Descriptor: Ribonuclease pancreatic, VHH Antibody
Authors:Fanning, S.W, Walter, R, Horn, J.R.
Deposit date:2014-02-26
Release date:2014-09-24
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
5W9D
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Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen
Descriptor: Endoxifen, Estrogen receptor
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2017-06-23
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6464 Å)
Cite:Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
Mol. Pharmacol., 94, 2018
5DXG
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BU of 5dxg by Molmil
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P5
Descriptor: ESTRADIOL, Estrogen receptor, GLYCEROL, ...
Authors:Fanning, S.W, Speltz, T.E, Mayne, C.G, Tajkhorshid, E, Greene, G.L, Moore, T.W.
Deposit date:2015-09-23
Release date:2016-07-27
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
Angew. Chem. Int. Ed. Engl., 55, 2016
5DXE
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Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P4 and Estradiol
Descriptor: ESTRADIOL, Estrogen receptor, Nuclear receptor coactivator 2
Authors:Fanning, S.W, Speltz, T.E, Mayne, C.G, Tajkhorshid, E, Greene, G.L, Moore, T.W.
Deposit date:2015-09-23
Release date:2016-08-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
Angew.Chem.Int.Ed.Engl., 55, 2016
3QXV
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Structure of an Anti-Methotrexate CDR1-4 Graft VHH Antibody in Complex with Methotrexate
Descriptor: Anti-Methotrexate CDR1-4 Graft VHH, METHOTREXATE, SULFATE ION
Authors:Fanning, S.W, Horn, J.R.
Deposit date:2011-03-02
Release date:2011-07-27
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop.
Protein Sci., 20, 2011
6PSJ
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BU of 6psj by Molmil
Bazedoxifene in Complex with Y537S Estrogen Receptor Alpha Ligand Binding Domain
Descriptor: Bazedoxifene, Estrogen receptor
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2019-07-12
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
Elife, 11, 2022
4PPT
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Engineered Dual Specific VHH Antibody in Complex with a Nickel (II) Ion
Descriptor: Engineered single domain VHH antibody, NICKEL (II) ION, SULFATE ION
Authors:Fanning, S.W, Walter, R, Horn, J.R.
Deposit date:2014-02-27
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
7UJ7
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BU of 7uj7 by Molmil
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411
Descriptor: 11alpha-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1(10),2,4-triene-3,17beta-diol, Estrogen receptor
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2022-03-30
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
Elife, 11, 2022
7KBS
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BU of 7kbs by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Raloxifene
Descriptor: Estrogen receptor, RALOXIFENE
Authors:Fanning, S.W.
Deposit date:2020-10-02
Release date:2020-11-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.834 Å)
Cite:Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
Elife, 11, 2022
4Q13
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Apo Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant with a glucocorticoid receptor-interacting protein 1 NR box II peptide
Descriptor: Estrogen receptor, Glucocorticoid receptor-interacting protein 1 NR box II peptide
Authors:Fanning, S.W, Panchamukhi, S, Greene, G.L.
Deposit date:2014-04-02
Release date:2015-04-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
4PXM
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BU of 4pxm by Molmil
The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with Estradiol and a glucocorticoid receptor-interacting protein 1 NR box II peptide
Descriptor: ESTRADIOL, Estrogen receptor, Nuclear receptor coactivator 2
Authors:Fanning, S.W, Panchamukhi, S, Greene, G.L.
Deposit date:2014-03-24
Release date:2015-04-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
4Q50
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BU of 4q50 by Molmil
The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with 4-hydroxytamoxifen
Descriptor: 4-HYDROXYTAMOXIFEN, Estrogen receptor, SULFATE ION
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2014-04-15
Release date:2015-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
7EGK
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BU of 7egk by Molmil
Bicarbonate transporter complex SbtA-SbtB bound to AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Membrane-associated protein SbtB, SODIUM ION, ...
Authors:Fang, S, Huang, X, Zhang, X, Zhang, P.
Deposit date:2021-03-24
Release date:2021-05-26
Last modified:2021-06-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA.
Proc.Natl.Acad.Sci.USA, 118, 2021
7EGL
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BU of 7egl by Molmil
Bicarbonate transporter complex SbtA-SbtB bound to HCO3-
Descriptor: BICARBONATE ION, Membrane-associated protein SbtB, SODIUM ION, ...
Authors:Fang, S, Huang, X, Zhang, X, Zhang, P.
Deposit date:2021-03-24
Release date:2021-05-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA.
Proc.Natl.Acad.Sci.USA, 118, 2021
3SWL
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BU of 3swl by Molmil
Crystal Structure Analysis of H74A Mutant of Human CLIC1
Descriptor: Chloride intracellular channel protein 1
Authors:Fanucchi, S, Achilonu, I.A, Fernandes, M.A, Dirr, H.W.
Deposit date:2011-07-14
Release date:2011-08-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
Biochemistry, 51, 2012
3P8W
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BU of 3p8w by Molmil
Crystal Structure Analysis of R29M/E81M double mutant of human CLIC1
Descriptor: Chloride intracellular channel protein 1
Authors:Fanucchi, S, Achilonu, I.A, Fernandes, M.A, Legg-E'Silva, D.A, Dirr, H.W.
Deposit date:2010-10-15
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure Analysis of R29M/E81M double mutant of human CLIC1
To be Published
3QR6
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Crystal Structure Analysis of H185F Mutant of Human CLIC1
Descriptor: Chloride intracellular channel protein 1
Authors:Fanucchi, S, Achilonu, I.A, Fernandes, M.A, Dirr, H.W.
Deposit date:2011-02-17
Release date:2011-03-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
Biochemistry, 51, 2012
3O3T
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Crystal Structure Analysis of M32A mutant of human CLIC1
Descriptor: Chloride intracellular channel protein 1
Authors:Fanucchi, S, Achilonu, I.A, Adamson, R.J, Fernandes, M.A, Stoychev, S, Dirr, H.W.
Deposit date:2010-07-26
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure Analysis of M32A mutant of human CLIC1
To be Published
3U6V
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Crystal Structure Analysis of L23A mutant of human GST A1-1
Descriptor: Glutathione S-transferase A1
Authors:Fanucchi, S, Achilonu, I.A, Khoza, T.N, Fernandes, M.A, Gildenhuys, S, Dirr, H.W.
Deposit date:2011-10-13
Release date:2011-10-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure Analysis of L23A mutant of human GST A1-1
To be Published
3UVH
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Crystal Structure Analysis of E81M mutant of human CLIC1
Descriptor: Chloride intracellular channel protein 1
Authors:Fanucchi, S, Achilonu, I.A, Fernandes, M.A, Legg-E'Silva, D.A, Stoychev, S.H, Dirr, H.W.
Deposit date:2011-11-30
Release date:2011-12-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Crystal Structure Analysis of E81M mutant of human CLIC1
To be Published

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