5DXE

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P4 and Estradiol

Summary for 5DXE

Entry DOI	10.2210/pdb5dxe/pdb
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, ESTRADIOL, ... (4 entities in total)
Functional Keywords	estrogen receptor alpha, stapled peptide, peptide mimetic, breast cancer, hormone, somatic mutation, hormone receptor-peptide complex, hormone receptor/peptide
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	63200.97
Authors	Fanning, S.W.,Speltz, T.E.,Mayne, C.G.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. (deposition date: 2015-09-23, release date: 2016-08-03, Last modification date: 2023-11-15)
Primary citation	Speltz, T.E.,Fanning, S.W.,Mayne, C.G.,Fowler, C.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew.Chem.Int.Ed.Engl., 55:4252-4255, 2016 Cited by PubMed: 26928945 DOI: 10.1002/anie.201510557 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation