5DXB
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol
Summary for 5DXB
Entry DOI | 10.2210/pdb5dxb/pdb |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, ESTRADIOL, ... (7 entities in total) |
Functional Keywords | estrogen receptor alpha, somatic mutataion, stapled peptide, peptide mimetic, hormone receptor, breast cancer, hormone receptor-peptide complex, hormone receptor/peptide |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 63218.21 |
Authors | Fanning, S.W.,Speltz, T.E.,Mayne, C.G.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. (deposition date: 2015-09-23, release date: 2016-07-27, Last modification date: 2020-02-19) |
Primary citation | Speltz, T.E.,Fanning, S.W.,Mayne, C.G.,Fowler, C.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew. Chem. Int. Ed. Engl., 55:4252-4255, 2016 Cited by PubMed: 26928945DOI: 10.1002/anie.201510557 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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