5DXB

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EST A 1000

Chain	Residue
A	MET343
A	LEU346
A	GLU353
A	ARG394
A	HIS524
A	LEU525

---

site_id	AC2
Number of Residues	8
Details	binding site for residue EST B 601

Chain	Residue
B	LEU387
B	ARG394
B	GLY521
B	HIS524
B	HOH707
B	MET343
B	LEU346
B	GLU353

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL B 602

Chain	Residue
B	ASN407
B	LEU408
B	LEU409

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL B 603

Chain	Residue
B	ASN439
B	GLN441
B	GLU444
B	MET490
B	ALA493
B	ARG503

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CL B 604

Chain	Residue
A	ARG352
A	HOH1159
B	ARG352
B	HOH718

---

site_id	AC6
Number of Residues	1
Details	binding site for Ligand NH2 D 13 bound to SER D 12

Chain	Residue
D	SER12

---

site_id	AC7
Number of Residues	10
Details	binding site for residues MK8 D 4 and 66D D 8

Chain	Residue
A	GLU542
A	HOH1107
B	TYR331
D	LYS3
D	LEU5
D	HIS6
D	ARG7
D	LEU9
D	GLN10
D	ASP11

---

site_id	AC8
Number of Residues	8
Details	binding site for Di-peptide LYS E 3 and MK8 E 4

Chain	Residue
B	GLU380
B	LEU539
B	GLU542
E	HIS2
E	LEU5
E	HIS6
E	ARG7
E	66D8

---

site_id	AC9
Number of Residues	10
Details	binding site for residues MK8 E 4 and 66D E 8

Chain	Residue
B	ILE358
B	LEU539
B	GLU542
E	LYS3
E	LEU5
E	HIS6
E	ARG7
E	LEU9
E	GLN10
E	ASP11

---

site_id	AD1
Number of Residues	7
Details	binding site for Di-peptide MK8 E 4 and LEU E 5

Chain	Residue
B	LEU539
B	GLU542
E	LYS3
E	HIS6
E	ARG7
E	66D8
E	LEU9

---

site_id	AD2
Number of Residues	9
Details	binding site for Di-peptide ARG E 7 and 66D E 8

Chain	Residue
A	PRO333
B	ILE358
E	LYS3
E	MK84
E	LEU5
E	HIS6
E	LEU9
E	GLN10
E	ASP11

---

site_id	AD3
Number of Residues	7
Details	binding site for Di-peptide 66D E 8 and LEU E 9

Chain	Residue
B	ILE358
E	MK84
E	LEU5
E	HIS6
E	ARG7
E	GLN10
E	ASP11

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
B	ILE358-GLU423
A	ARG394
A	HIS524

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
B	ILE358-LEU378
B	ARG394-VAL418

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE

Chain	Residue	Details
B	TYR526

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153

Chain	Residue	Details
B	ALA340

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420

Chain	Residue	Details
B	SER433

---