5DXB
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue EST A 1000 |
| Chain | Residue |
| A | MET343 |
| A | LEU346 |
| A | GLU353 |
| A | ARG394 |
| A | HIS524 |
| A | LEU525 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EST B 601 |
| Chain | Residue |
| B | LEU387 |
| B | ARG394 |
| B | GLY521 |
| B | HIS524 |
| B | HOH707 |
| B | MET343 |
| B | LEU346 |
| B | GLU353 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | ASN407 |
| B | LEU408 |
| B | LEU409 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | ASN439 |
| B | GLN441 |
| B | GLU444 |
| B | MET490 |
| B | ALA493 |
| B | ARG503 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 604 |
| Chain | Residue |
| A | ARG352 |
| A | HOH1159 |
| B | ARG352 |
| B | HOH718 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for Ligand NH2 D 13 bound to SER D 12 |
| Chain | Residue |
| D | SER12 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residues MK8 D 4 and 66D D 8 |
| Chain | Residue |
| A | GLU542 |
| A | HOH1107 |
| B | TYR331 |
| D | LYS3 |
| D | LEU5 |
| D | HIS6 |
| D | ARG7 |
| D | LEU9 |
| D | GLN10 |
| D | ASP11 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide LYS E 3 and MK8 E 4 |
| Chain | Residue |
| B | GLU380 |
| B | LEU539 |
| B | GLU542 |
| E | HIS2 |
| E | LEU5 |
| E | HIS6 |
| E | ARG7 |
| E | 66D8 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residues MK8 E 4 and 66D E 8 |
| Chain | Residue |
| B | ILE358 |
| B | LEU539 |
| B | GLU542 |
| E | LYS3 |
| E | LEU5 |
| E | HIS6 |
| E | ARG7 |
| E | LEU9 |
| E | GLN10 |
| E | ASP11 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide MK8 E 4 and LEU E 5 |
| Chain | Residue |
| B | LEU539 |
| B | GLU542 |
| E | LYS3 |
| E | HIS6 |
| E | ARG7 |
| E | 66D8 |
| E | LEU9 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide ARG E 7 and 66D E 8 |
| Chain | Residue |
| A | PRO333 |
| B | ILE358 |
| E | LYS3 |
| E | MK84 |
| E | LEU5 |
| E | HIS6 |
| E | LEU9 |
| E | GLN10 |
| E | ASP11 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide 66D E 8 and LEU E 9 |
| Chain | Residue |
| B | ILE358 |
| E | MK84 |
| E | LEU5 |
| E | HIS6 |
| E | ARG7 |
| E | GLN10 |
| E | ASP11 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
