5DXB
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 261 | 29820.2 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (B) | Estrogen receptor | polymer | 261 | 29774.1 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (D, E) | Nuclear receptor coactivator 2 | polymer | 13 | 1429.7 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 4 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
| 5 | G, H (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | I (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | J, K, L (A, B, D) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A: 297 - 554 (UniProt: P03372)
B: 297 - 554 (UniProt: P03372)
D, E: 2 - 12 (UniProt: Q15596)
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | initiating methionine |
| Asp 295 | - | expression tag |
| Pro 296 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | initiating methionine |
| Asp 295 | - | expression tag |
| Pro 296 | - | expression tag |
| Ser 537 | Tyr 364 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| Mk8 4 | Ile 689 | conflict |
| 66d 8 | Leu 693 | conflict |
| Nh2 13 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62453.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 764.4 | |
| All* | Total formula weight | 63218.2 |
