5DXB
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 261 | 29820.2 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (B) | Estrogen receptor | polymer | 261 | 29774.1 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (D, E) | Nuclear receptor coactivator 2 | polymer | 13 | 1429.7 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 4 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) PubChem (1807201) PubChem (450) PubChem (5757) PubChem (5998) PubChem (10596) PubChem (14880) PubChem (68570) PubChem (667480) PubChem (667515) PubChem (721867) PubChem (928284) PubChem (1258565) PubChem (5317221) PubChem (5745505) PubChem (6328313) PubChem (6432565) PubChem (6560352) PubChem (6603846) PubChem (6918968) PubChem (6919041) PubChem (7000012) PubChem (7004689) PubChem (7048584) PubChem (7048670) PubChem (7061189) PubChem (7067800) PubChem (9795489) PubChem (9811784) PubChem (9903595) PubChem (9938293) PubChem (11869602) PubChem (11870431) PubChem (12313787) PubChem (12313791) PubChem (12313794) PubChem (16757676) PubChem (43912931) PubChem (44284023) PubChem (177015577) PubChem (46781508) PubChem (1807200) PubChem (5317222) PubChem (54403267) PubChem (56624791) PubChem (57041922) PubChem (12313788) PubChem (58650893) PubChem (59084698) PubChem (162947701) PubChem (166849971) PubChem (68014581) PubChem (68209947) PubChem (70220248) PubChem (70864205) PubChem (91740223) PubChem (101691329) PubChem (118548795) PubChem (126969992) PubChem (129010410) PubChem (129317336) PubChem (130307439) PubChem (130307440) PubChem (143489158) PubChem (144605119) PubChem (145157829) PubChem (145610824) PubChem (154109755) PubChem (172873304) | |||
| 5 | G, H (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 6 | I (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 7 | J, K, L (A, B, D) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A: 297 - 554 (UniProt: P03372)
B: 297 - 554 (UniProt: P03372)
D, E: 2 - 12 (UniProt: Q15596)
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | initiating methionine |
| Asp 295 | - | expression tag |
| Pro 296 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | initiating methionine |
| Asp 295 | - | expression tag |
| Pro 296 | - | expression tag |
| Ser 537 | Tyr 364 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| Mk8 4 | Ile 689 | conflict |
| 66d 8 | Leu 693 | conflict |
| Nh2 13 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62453.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 764.4 | |
| All* | Total formula weight | 63218.2 |
