6VPF

Estrogen Receptor Alpha Ligand Binding Domain in Complex with the Selective Estrogen Receptor Modulator Clomiphene

Summary for 6VPF

Entry DOI	10.2210/pdb6vpf/pdb
Descriptor	Estrogen receptor, Clomifene (3 entities in total)
Functional Keywords	breast cancer, hormone, selective estrogen receptor modulator, antiestrogen, alpha helical bundle, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	122412.64
Authors	Fanning, S.W.,Greene, G.L. (deposition date: 2020-02-03, release date: 2020-09-16, Last modification date: 2023-10-11)
Primary citation	Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W. Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11:-, 2022 Cited by PubMed: 35575456 DOI: 10.7554/eLife.72512 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation