6PSJ

Bazedoxifene in Complex with Y537S Estrogen Receptor Alpha Ligand Binding Domain

Summary for 6PSJ

• Entry DOI: 10.2210/pdb6psj/pdb
• Descriptor: Estrogen receptor, Bazedoxifene (3 entities in total)
• Functional Keywords: estrogen receptor, y537s, bazedoxifene, steroid, hormone, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 61009.26

Authors

Fanning, S.W.,Greene, G.L. (deposition date: 2019-07-12, release date: 2019-11-20, Last modification date: 2023-10-11)

• Primary citation: Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W.; Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.; Elife, 11:-, 2022; PubMed: 35575456; DOI: 10.7554/eLife.72512

Experimental method

X-RAY DIFFRACTION (1.8 Å)