7UJ7

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411

Replaces:  6VJ1

Summary for 7UJ7

• Entry DOI: 10.2210/pdb7uj7/pdb
• Descriptor: Estrogen receptor, 11alpha-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1(10),2,4-triene-3,17beta-diol (3 entities in total)
• Functional Keywords: estrogen receptor, hormone, serm, ru39411, activating mutations, y537s, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 122331.14

Authors

Fanning, S.W.,Greene, G.L. (deposition date: 2022-03-30, release date: 2022-05-04, Last modification date: 2023-10-18)

• Primary citation: Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W.; Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.; Elife, 11:-, 2022; PubMed: 35575456; DOI: 10.7554/eLife.72512

Experimental method

X-RAY DIFFRACTION (1.68 Å)