3QXV

Structure of an Anti-Methotrexate CDR1-4 Graft VHH Antibody in Complex with Methotrexate

Summary for 3QXV

• Entry DOI: 10.2210/pdb3qxv/pdb
• Related: 1I3U 2x6m 3QXT 3QXU 3QXW
• Descriptor: Anti-Methotrexate CDR1-4 Graft VHH, METHOTREXATE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: camelid single domain antibody, heavy chain only, vhh, antibody, anti-hapten antibody, cdr, hapten binding, small molecule sensing, ligand binding, low molecular weight compound, methotrexate, immune system
• Biological source: Lama Glama (Llama)
• Total number of polymer chains: 5
• Total formula weight: 71467.27

Authors

Fanning, S.W.,Horn, J.R. (deposition date: 2011-03-02, release date: 2011-07-27, Last modification date: 2013-09-11)

• Primary citation: Fanning, S.W.,Horn, J.R.; An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop.; Protein Sci., 20:1196-1207, 2011; PubMed: 21557375; DOI: 10.1002/pro.648

Experimental method

X-RAY DIFFRACTION (2.5 Å)