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PDB: 39 件

6NWQ
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Chronic traumatic encephalopathy Type II Tau filament
分子名称: Microtubule-associated protein tau
著者Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W.
登録日2019-02-07
公開日2019-03-27
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature, 568, 2019
6NWP
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Chronic traumatic encephalopathy Type I Tau filament
分子名称: Microtubule-associated protein tau
著者Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W.
登録日2019-02-07
公開日2019-03-27
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature, 568, 2019
6GX5
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Narrow Pick Filament from Pick's disease brain
分子名称: Microtubule-associated protein tau
著者Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M.
登録日2018-06-26
公開日2018-09-12
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature, 561, 2018
6HRE
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Paired helical filament from sporadic Alzheimer's disease brain
分子名称: Microtubule-associated protein tau
著者Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M.
登録日2018-09-26
公開日2018-10-10
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
6HRF
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Straight filament from sporadic Alzheimer's disease brain
分子名称: Microtubule-associated protein tau
著者Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M.
登録日2018-09-26
公開日2018-10-10
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
1NLM
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CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX
分子名称: GLYCEROL, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
著者Hu, Y, Chen, L, Ha, S, Gross, B, Falcone, B, Walker, D, Mokhtarzadeh, M, Walker, S.
登録日2003-01-07
公開日2003-02-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
Proc.Natl.Acad.Sci.USA, 100, 2003
6QJP
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Cryo-EM structure of heparin-induced 2N4R tau jagged filaments
分子名称: Microtubule-associated protein tau
著者Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W.
登録日2019-01-24
公開日2019-02-20
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
6QJH
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Cryo-EM structure of heparin-induced 2N4R tau snake filaments
分子名称: Microtubule-associated protein tau
著者Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W.
登録日2019-01-24
公開日2019-02-20
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
6QJM
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Cryo-EM structure of heparin-induced 2N4R tau twister filaments
分子名称: Microtubule-associated protein tau
著者Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W.
登録日2019-01-24
公開日2019-02-27
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
6QJQ
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Cryo-EM structure of heparin-induced 2N3R tau filaments
分子名称: Microtubule-associated protein tau
著者Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W.
登録日2019-01-24
公開日2019-02-20
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
7Q4B
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Type I beta-amyloid 42 Filaments from Human Brain
分子名称: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
著者Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
登録日2021-10-30
公開日2021-11-24
最終更新日2023-03-08
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
7Q4M
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Type II beta-amyloid 42 Filaments from Human Brain
分子名称: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
著者Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
登録日2021-11-01
公開日2021-11-24
最終更新日2023-03-08
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
7P6A
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Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7P6C
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Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7P6B
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Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7PY2
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Structure of pathological TDP-43 filaments from ALS with FTLD
分子名称: TAR DNA-binding protein 43
著者Arseni, D, Hasegawa, H, Murzin, A.G, Kametani, F, Arai, M, Yoshida, M, Falcon, B.
登録日2021-10-08
公開日2021-12-15
最終更新日2022-01-19
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structure of pathological TDP-43 filaments from ALS with FTLD.
Nature, 601, 2022
7P68
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Globular glial tauopathy type 3 tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7P67
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Globular glial tauopathy type 2 tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7P6E
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Argyrophilic grain disease type 2 tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7P6D
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Argyrophilic grain disease type 1 tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7P65
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Progressive supranuclear palsy tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7P66
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Globular glial tauopathy type 1 tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
8CG3
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Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 1)
分子名称: TAR DNA-binding protein 43
著者Arseni, D, Ryskeldi-Falcon, B.
登録日2023-02-03
公開日2023-08-02
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (2.39 Å)
主引用文献TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
Nature, 620, 2023
8CGG
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Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 2)
分子名称: TAR DNA-binding protein 43
著者Arseni, D, Ryskeldi-Falcon, B.
登録日2023-02-04
公開日2023-08-02
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
Nature, 620, 2023
8CGH
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Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 3)
分子名称: TAR DNA-binding protein 43
著者Arseni, D, Ryskeldi-Falcon, B.
登録日2023-02-04
公開日2023-08-02
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (2.68 Å)
主引用文献TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
Nature, 620, 2023

 

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