7PY2
Structure of pathological TDP-43 filaments from ALS with FTLD
Summary for 7PY2
| Entry DOI | 10.2210/pdb7py2/pdb |
| EMDB information | 13708 |
| Descriptor | TAR DNA-binding protein 43 (1 entity in total) |
| Functional Keywords | tdp-43, als, amyotrophic lateral sclerosis, ftd, frontotemporal dementia, ftld, frontotemporal lobar degeneration, amyloid, filament, fibril, neurodegenerative, neurodegeneration, protein fibril |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 179138.97 |
| Authors | Arseni, D.,Hasegawa, H.,Murzin, A.G.,Kametani, F.,Arai, M.,Yoshida, M.,Falcon, B. (deposition date: 2021-10-08, release date: 2021-12-15, Last modification date: 2022-01-19) |
| Primary citation | Arseni, D.,Hasegawa, M.,Murzin, A.G.,Kametani, F.,Arai, M.,Yoshida, M.,Ryskeldi-Falcon, B. Structure of pathological TDP-43 filaments from ALS with FTLD. Nature, 601:139-143, 2022 Cited by PubMed: 34880495DOI: 10.1038/s41586-021-04199-3 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
Download full validation report
