8CGG
Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 2)
Summary for 8CGG
| Entry DOI | 10.2210/pdb8cgg/pdb |
| EMDB information | 16642 |
| Descriptor | TAR DNA-binding protein 43 (1 entity in total) |
| Functional Keywords | tdp-43, ftd, ftld, amyloid, filaments, fibril, neurodegeneration, neurodegenerative disease, rbp, rna-binding protein, lcd, low-complexity domain, frontotemporal dementia, frontotemporal lobar degeneration, pathological, protein fibril, rna binding protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 5 |
| Total formula weight | 223923.71 |
| Authors | Arseni, D.,Ryskeldi-Falcon, B. (deposition date: 2023-02-04, release date: 2023-08-02, Last modification date: 2023-08-30) |
| Primary citation | Arseni, D.,Chen, R.,Murzin, A.G.,Peak-Chew, S.Y.,Garringer, H.J.,Newell, K.L.,Kametani, F.,Robinson, A.C.,Vidal, R.,Ghetti, B.,Hasegawa, M.,Ryskeldi-Falcon, B. TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP. Nature, 620:898-903, 2023 Cited by PubMed: 37532939DOI: 10.1038/s41586-023-06405-w PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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