6QJH

Cryo-EM structure of heparin-induced 2N4R tau snake filaments

Summary for 6QJH

• Entry DOI: 10.2210/pdb6qjh/pdb
• EMDB information: 4563
• Descriptor: Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: recombinant tau protein, heparin, filament, cross-beta structure, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 18672.66

Authors

Zhang, W.,Falcon, B.,Murzin, A.G.,Fan, J.,Crowther, R.A.,Goedert, M.,Scheres, S.H.W. (deposition date: 2019-01-24, release date: 2019-02-20)

• Primary citation: Zhang, W.,Falcon, B.,Murzin, A.G.,Fan, J.,Crowther, R.A.,Goedert, M.,Scheres, S.H.; Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.; Elife, 8:-, 2019; PubMed: 30720432; DOI: 10.7554/eLife.43584

Experimental method

ELECTRON MICROSCOPY (3.3 Å)