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PDB: 153 results

7S37
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Cas9:sgRNA (S. pyogenes) in the open-protein conformation
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Single-guide RNA
Authors:Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A.
Deposit date:2021-09-04
Release date:2022-04-20
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
7S38
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Cas9:sgRNA:DNA (S. pyogenes) forming a 3-base-pair R-loop
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ...
Authors:Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A.
Deposit date:2021-09-04
Release date:2022-04-20
Last modified:2022-05-04
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
7S3H
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Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, open-protein/linear-DNA conformation
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ...
Authors:Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A.
Deposit date:2021-09-06
Release date:2022-04-20
Last modified:2022-05-04
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
7S36
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Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, closed-protein/bent-DNA conformation
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ...
Authors:Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A.
Deposit date:2021-09-04
Release date:2022-04-20
Last modified:2022-05-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:CRISPR-Cas9 bends and twists DNA to read its sequence.
Nat.Struct.Mol.Biol., 29, 2022
5I4A
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X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA
Descriptor: Argonaute protein, RNA (5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*U)-3')
Authors:Doxzen, K.W, Kaya, E, Knoll, K.R, Wilson, R.C, Strutt, S.C, Kranzusch, P.J, Doudna, J.A.
Deposit date:2016-02-11
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:A bacterial Argonaute with noncanonical guide RNA specificity.
Proc.Natl.Acad.Sci.USA, 113, 2016
5WLH
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Crystal structure of LbaCas13a H328A (C2c2) bound to pre-crRNA (24-nt spacer)
Descriptor: GLYCEROL, IODIDE ION, LbaCas13a H328A (C2c2), ...
Authors:Knott, G.J, Doudna, J.A.
Deposit date:2017-07-26
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.80001032 Å)
Cite:Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
Nat. Struct. Mol. Biol., 24, 2017
8FYA
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Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex
Descriptor: Cas1, Cas2-DEDDh, DNA (28-MER), ...
Authors:Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
Deposit date:2023-01-25
Release date:2023-05-03
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FY9
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Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex
Descriptor: Cas1, Cas2-DEDDh, DNA (28-MER)
Authors:Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
Deposit date:2023-01-25
Release date:2023-05-03
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
5VVJ
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Cas1-Cas2 bound to half-site intermediate
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (112-MER), ...
Authors:Wright, A.V, Knott, G.J, Doxzen, K.W, Doudna, J.A.
Deposit date:2017-05-19
Release date:2017-08-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.89 Å)
Cite:Structures of the CRISPR genome integration complex.
Science, 357, 2017
7ZP8
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70S E. coli ribosome with a stalled filamin domain 5 nascent chain
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Mitropoulou, A, Plessa, E, Wlodarski, T, Ahn, M, Chan, S.H.S, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J.
Deposit date:2022-04-26
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Modulating co-translational protein folding by rational design and ribosome engineering.
Nat Commun, 13, 2022
7ZQ6
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70S E. coli ribosome with truncated uL23 and uL24 loops and a stalled filamin domain 5 nascent chain
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Mitropoulou, A, Wlodarski, T, Ahn, M, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J.
Deposit date:2022-04-29
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Modulating co-translational protein folding by rational design and ribosome engineering.
Nat Commun, 13, 2022
7ZOD
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BU of 7zod by Molmil
70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Mitropoulou, A, Plessa, E, Wlodarski, T, Ahn, M, Sidhu, H, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J.
Deposit date:2022-04-25
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (2.56 Å)
Cite:Modulating co-translational protein folding by rational design and ribosome engineering.
Nat Commun, 13, 2022
7ZQ5
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BU of 7zq5 by Molmil
70S E. coli ribosome with truncated uL23 and uL24 loops
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Mitropoulou, A, Wlodarski, T, Ahn, M, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J.
Deposit date:2022-04-29
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Modulating co-translational protein folding by rational design and ribosome engineering.
Nat Commun, 13, 2022
5A15
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BU of 5a15 by Molmil
Crystal structure of the BTB domain of human KCTD16
Descriptor: BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD16
Authors:Pinkas, D.M, Sanvitale, C.E, Solcan, N, Goubin, S, Canning, P, Dixon Clarke, S.E, Talon, R, Wiggers, H.J, Fitzpatrick, F, Tallant, C, Kopec, J, Chalk, R, Doutch, J, Krojer, T, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.
Deposit date:2015-04-28
Release date:2015-11-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Biochem. J., 474, 2017
7Z20
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BU of 7z20 by Molmil
70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia and a stalled filamin domain 5 nascent chain
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Mitropoulou, A, Plessa, E, Wlodarski, T, Ahn, M, Sidhu, H, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J.
Deposit date:2022-02-25
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (2.29 Å)
Cite:Modulating co-translational protein folding by rational design and ribosome engineering.
Nat Commun, 13, 2022
1GMY
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BU of 1gmy by Molmil
Cathepsin B complexed with dipeptidyl nitrile inhibitor
Descriptor: 2-AMINOETHANIMIDIC ACID, 3-METHYLPHENYLALANINE, CATHEPSIN B, ...
Authors:Greenspan, P.D, Clark, K.L, Tommasi, R.A, Cowen, S.D, McQuire, L.W, Farley, D.L, van Duzer, J.H, Goldberg, R.L, Zhou, H, Du, Z, Fitt, J.J, Coppa, D.E, Fang, Z, Macchia, W, Zhu, L, Capparelli, M.P, Goldstein, R, Wigg, A.M, Doughty, J.R, Bohacek, R.S, Knap, A.K.
Deposit date:2001-09-25
Release date:2002-09-19
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design
J.Med.Chem., 44, 2001
5CFN
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BU of 5cfn by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p]
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFP
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Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]'
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.066 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFL
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Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CITRATE ANION, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.836 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFM
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Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p]
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CITRATE ANION, Stimulator of Interferon Genes
Authors:Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
Deposit date:2015-07-08
Release date:2015-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5DS5
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BU of 5ds5 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA and Mg
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
Deposit date:2015-09-16
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.951 Å)
Cite:Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
4PR6
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BU of 4pr6 by Molmil
A Second Look at the HDV Ribozyme Structure and Dynamics.
Descriptor: HDV RIBOZYME SELF-CLEAVED, MAGNESIUM ION, U1 small nuclear ribonucleoprotein A
Authors:Kapral, G.J, Jain, S, Noeske, J, Doudna, J.A, Richardson, D.C, Richardson, J.S.
Deposit date:2014-03-05
Release date:2014-10-29
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:New tools provide a second look at HDV ribozyme structure, dynamics and cleavage.
Nucleic Acids Res., 42, 2014
4P6I
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BU of 4p6i by Molmil
Crystal structure of the Cas1-Cas2 complex from Escherichia coli
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2
Authors:Nunez, J.K, Kranzusch, P.J, Noeske, J, Doudna, J.A.
Deposit date:2014-03-24
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.
Nat.Struct.Mol.Biol., 21, 2014
1GID
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BU of 1gid by Molmil
CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING
Descriptor: COBALT HEXAMMINE(III), MAGNESIUM ION, P4-P6 RNA RIBOZYME DOMAIN
Authors:Cate, J.H, Gooding, A.R, Podell, E, Zhou, K, Golden, B.L, Kundrot, C.E, Cech, T.R, Doudna, J.A.
Deposit date:1996-08-22
Release date:1996-12-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a group I ribozyme domain: principles of RNA packing.
Science, 273, 1996
2Y9H
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Structure A of CRISPR endoribonuclease Cse3 bound to 19 nt RNA
Descriptor: 5'-R(*UP*CP*CP*CP*CP*AP*CP*GP*CP*GP*UP*GP*UP*GP *GP*GP*DGP*AP*UP)-3', CSE3
Authors:Sashital, D.G, Jinek, M, Doudna, J.A.
Deposit date:2011-02-14
Release date:2011-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An RNA-Induced Conformational Change Required for Crispr RNA Cleavage by the Endoribonuclease Cse3.
Nat.Struct.Mol.Biol., 18, 2011

221716

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