5VGB

Crystal structure of NmeCas9 HNH domain bound to anti-CRISPR AcrIIC1

Summary for 5VGB

Entry DOI	10.2210/pdb5vgb/pdb
Descriptor	CRISPR-associated endonuclease Cas9, Anti-CRISPR protein (AcrIIC1), GLYCEROL, ... (5 entities in total)
Functional Keywords	protein, rna, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Neisseria meningitidis More
Total number of polymer chains	2
Total formula weight	26816.00
Authors	Harrington, L.B.,Doxzen, K.W.,Ma, E.,Knott, G.J.,Kranzusch, P.J.,Doudna, J.A. (deposition date: 2017-04-10, release date: 2017-08-30, Last modification date: 2024-03-13)
Primary citation	Harrington, L.B.,Doxzen, K.W.,Ma, E.,Liu, J.J.,Knott, G.J.,Edraki, A.,Garcia, B.,Amrani, N.,Chen, J.S.,Cofsky, J.C.,Kranzusch, P.J.,Sontheimer, E.J.,Davidson, A.R.,Maxwell, K.L.,Doudna, J.A. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell, 170:1224-1233.e15, 2017 Cited by PubMed: 28844692 DOI: 10.1016/j.cell.2017.07.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.497 Å)

Structure validation