6ZYA
 
 | | Extended human uromodulin filament core at 3.5 A resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R. | | 登録日 | 2020-07-31 | | 公開日 | 2020-09-02 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
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6H6F
 | | PTC3 holotoxin complex from Photorhabdus luminiscens - Mutant TcC-D651A | | 分子名称: | TcdA1, TcdB2,TccC3,TccC3 | | 著者 | Gatsogiannis, C, Merino, F, Roderer, D, Balchin, D, Schubert, E, Kuhlee, A, Hayer-Hartl, M, Raunser, S. | | 登録日 | 2018-07-27 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Tc toxin activation requires unfolding and refolding of a beta-propeller.
Nature, 563, 2018
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6GOC
 | | Methylesterase BT1017 | | 分子名称: | DUF3826 domain-containing protein, ZINC ION | | 著者 | Basle, A, Ndeh, D, Gilbert, H. | | 登録日 | 2018-06-01 | | 公開日 | 2019-06-19 | | 最終更新日 | 2020-04-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Characterisation of a methylesterases essential for pectin rhamnogalacturonan II metabolism from the gut bacterium Bacteroides thetaiotaomicron
to be published
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7PQY
 | | Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FI-3A Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, FI-3A Fab heavy chain, FI-3A Fab light chain, ... | | 著者 | Zhou, D, Ren, J, Stuart, D. | | 登録日 | 2021-09-20 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2.
Theranostics, 12, 2022
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6H07
 | | X-ray structure of Lactobacillus brevis alcohol dehydrogenase | | 分子名称: | MAGNESIUM ION, MANGANESE (II) ION, R-specific alcohol dehydrogenase | | 著者 | Hermann, J, Nowotny, P, Biggel, P, Schneider, S, Hekmat, D, Weuster-Botz, D. | | 登録日 | 2018-07-06 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.482 Å) | | 主引用文献 | Neutron and X-ray crystal structures of Lactobacillus brevis alcohol dehydrogenase reveal new insights into hydrogen-bonding pathways.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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6Z3Z
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1W9M
 | | AS-isolated hybrid cluster protein from Desulfovibrio vulgaris X-ray structure at 1.35A resolution using iron anomalous signal | | 分子名称: | FE-S-O HYBRID CLUSTER, HYDROXYLAMINE REDUCTASE, IRON/SULFUR CLUSTER | | 著者 | Aragao, D, Macedo, S, Mitchell, E.P, Coelho, D, Romao, C.V, Teixeira, M, Lindley, P.F. | | 登録日 | 2004-10-14 | | 公開日 | 2005-02-04 | | 最終更新日 | 2023-03-29 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Structural and Functional Relationships in the Hybrid Cluster Protein Family:Structure of the Anaerobically Purified Hybrid Cluster Protein from Desulfovibrio Vulgaris at 1.35 A Resolution
Acta Crystallogr.,Sect.D, 64, 2008
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8QV0
 | | Structure of the native microtubule lattice nucleated from the yeast spindle pole body | | 分子名称: | Tubulin alpha-1 chain, Tubulin beta chain | | 著者 | Dendooven, T, Yatskevich, S, Burt, A, Bellini, D, Kilmartin, J, Barford, D. | | 登録日 | 2023-10-17 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Structure of the native gamma-tubulin ring complex capping spindle microtubules.
Nat.Struct.Mol.Biol., 31, 2024
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6HUP
 | | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, GAMMA-AMINO-BUTANOIC ACID, ... | | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | | 登録日 | 2018-10-09 | | 公開日 | 2019-01-02 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
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7A5O
 | | Human MUC2 AAs 21-1397 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Javitt, G, Khmelnitsky, L, Albert, L, Elad, N, Ilani, T, Diskin, R, Fass, D. | | 登録日 | 2020-08-21 | | 公開日 | 2020-10-21 | | 最終更新日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Assembly Mechanism of Mucin and von Willebrand Factor Polymers.
Cell, 183, 2020
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8SY5
 | | E. coli DNA-directed RNA polymerase transcription elongation complex bound the unnatural dS-BTP base pair in the active site | | 分子名称: | 2-oxo-2-hydroadenosine 5'-(tetrahydrogen triphosphate), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Shan, Z, Lyumkis, D, Oh, J, Wang, D. | | 登録日 | 2023-05-24 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase.
Nat Commun, 14, 2023
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8SY7
 | | E. coli DNA-directed RNA polymerase transcription elongation complex bound the unnatural dB-STP base pair in the active site | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Shan, Z, Lyumkis, D, Oh, J, Wang, D. | | 登録日 | 2023-05-24 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase.
Nat Commun, 14, 2023
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8SY6
 | | E. coli DNA-directed RNA polymerase transcription elongation complex bound the unnatural dB-UTP base pair in the active site | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Shan, Z, Lyumkis, D, Oh, J, Wang, D. | | 登録日 | 2023-05-24 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase.
Nat Commun, 14, 2023
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6G9X
 | | Crystal structure of a MFS transporter at 2.54 Angstroem resolution | | 分子名称: | 2-sulfanylbenzoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MERCURY (II) ION, ... | | 著者 | Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. | | 登録日 | 2018-04-11 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Mechanistic basis of L-lactate transport in the SLC16 solute carrier family.
Nat Commun, 10, 2019
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7RA7
 | | Crystal structure of rabbit anti-HIV Fab 11A | | 分子名称: | 11A Fab heavy chain, 11A Fab light chain, PENTAETHYLENE GLYCOL, ... | | 著者 | Oyen, D, Wilson, I.A. | | 登録日 | 2021-06-30 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions
To Be Published
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1UWH
 | | The complex of wild type B-RAF and BAY439006. | | 分子名称: | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, CHLORIDE ION | | 著者 | Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project | | 登録日 | 2004-02-05 | | 公開日 | 2004-03-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
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5VWR
 | | E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)-alpha-ketoglutarate | | 分子名称: | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-glutamic acid, Aspartate aminotransferase, GLYCEROL | | 著者 | Mascarenhas, R, Liu, D, Le, H, Silverman, R. | | 登録日 | 2017-05-22 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
Biochemistry, 56, 2017
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1UT5
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1UT8
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5VZ4
 | | Receptor-growth factor crystal structure at 2.20 Angstrom resolution | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, GDNF family receptor alpha-like, ... | | 著者 | Lakshminarasimhan, D, White, A, Suto, R.K. | | 登録日 | 2017-05-26 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
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1P83
 | | NMR STRUCTURE OF 1-25 FRAGMENT OF MYCOBACTERIUM TUBERCULOSIS CPN10 | | 分子名称: | 10 kDa chaperonin | | 著者 | Ciutti, A, Spiga, O, Giannozzi, E, Scarselli, M, Di Maro, D, Calamandrei, D, Niccolai, N, Bernini, A. | | 登録日 | 2003-05-06 | | 公開日 | 2003-05-27 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of 1-25 fragment of Cpn10 from Mycobacterium Tuberculosis
To be Published
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8RU1
 | | Chromatin remodeling regulator CECR2 with in crystallo disulfide bond | | 分子名称: | Chromatin remodeling regulator CECR2, GLYCEROL, SODIUM ION | | 著者 | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | | 登録日 | 2024-01-29 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants
To Be Published
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1UWJ
 | | The complex of mutant V599E B-RAF and BAY439006. | | 分子名称: | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE | | 著者 | Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project | | 登録日 | 2004-02-05 | | 公開日 | 2004-03-19 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
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8RQF
 | | Cryo-EM structure of human NTCP-Bulevirtide complex | | 分子名称: | Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ... | | 著者 | Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P. | | 登録日 | 2024-01-18 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Cryo-EM structure of human NTCP-Bulevirtide complex
To Be Published
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8RU5
 | | ATPase family AAA domain containing 2 with crystallization epitope mutations V1022R:Q1027E | | 分子名称: | 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2 | | 著者 | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | | 登録日 | 2024-01-30 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants
To Be Published
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