6HUP

CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38.

Summary for 6HUP

Entry DOI	10.2210/pdb6hup/pdb
EMDB information	0283
Descriptor	Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, GAMMA-AMINO-BUTANOIC ACID, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, ... (11 entities in total)
Functional Keywords	gabaar, membrane protein, cys-loop, plgic
Biological source	Bos taurus (Bovine) More
Total number of polymer chains	6
Total formula weight	337547.37
Authors	Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Jasenko, Z.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. (deposition date: 2018-10-09, release date: 2019-01-02, Last modification date: 2023-11-15)
Primary citation	Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565:454-459, 2019 Cited by PubMed: 30602790 DOI: 10.1038/s41586-018-0832-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.58 Å)

Structure validation