5VWR

E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)-alpha-ketoglutarate

Summary for 5VWR

Entry DOI	10.2210/pdb5vwr/pdb
Related	5VWO 5VWQ
Descriptor	Aspartate aminotransferase, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-glutamic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	aspartate aminotransferase, mechanism-based inactivator, ketimine, (1r, 3s, 4s)-3-amino-4-fluorocyclopentane-1-carboxylic acid (fcp), alpha-ketoglutarate, transferase
Biological source	Escherichia coli (strain K12)
Cellular location	Cytoplasm: P00509
Total number of polymer chains	1
Total formula weight	44455.94
Authors	Mascarenhas, R.,Liu, D.,Le, H.,Silverman, R. (deposition date: 2017-05-22, release date: 2017-09-13, Last modification date: 2024-03-13)
Primary citation	Mascarenhas, R.,Le, H.V.,Clevenger, K.D.,Lehrer, H.J.,Ringe, D.,Kelleher, N.L.,Silverman, R.B.,Liu, D. Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry, 56:4951-4961, 2017 Cited by PubMed: 28816437 DOI: 10.1021/acs.biochem.7b00499 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation