5VWQ

E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)

Summary for 5VWQ

Related5VWO
DescriptorAspartate aminotransferase, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE (3 entities in total)
Functional Keywordsaspartate aminotransferase, pmp, mechanism-based inactivator, (1r, 3s, 4s)-3-amino-4-fluorocyclopentane-1-carboxylic acid (fcp), transferase
Biological sourceEscherichia coli K-12
Cellular locationCytoplasm P00509
Total number of polymer chains4
Total molecular weight175469.55
Authors
Mascarenhas, R.,Lehrer, H.,Liu, D.,Ringe, D. (deposition date: 2017-05-22, release date: 2017-08-30, Last modification date: 2017-10-04)
Primary citation
Mascarenhas, R.,Le, H.V.,Clevenger, K.D.,Lehrer, H.J.,Ringe, D.,Kelleher, N.L.,Silverman, R.B.,Liu, D.
Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
Biochemistry, 56:4951-4961, 2017
PubMed: 28816437 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.7b00499
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19550.3%1.6%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-07-29