5VWO
Ornithine aminotransferase inactivated by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)
Summary for 5VWO
Entry DOI | 10.2210/pdb5vwo/pdb |
Related | 5VWQ 5VWR |
Descriptor | Ornithine aminotransferase, mitochondrial, (1S,3S,4E)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid (3 entities in total) |
Functional Keywords | aminotransferase, mechanism-based inactivator, plp, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 135655.81 |
Authors | Mascarenhas, R.,Liu, D.,Le, H.,Silverman, R. (deposition date: 2017-05-22, release date: 2017-08-30, Last modification date: 2023-10-04) |
Primary citation | Mascarenhas, R.,Le, H.V.,Clevenger, K.D.,Lehrer, H.J.,Ringe, D.,Kelleher, N.L.,Silverman, R.B.,Liu, D. Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry, 56:4951-4961, 2017 Cited by PubMed: 28816437DOI: 10.1021/acs.biochem.7b00499 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.773 Å) |
Structure validation
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