5VWO

Ornithine aminotransferase inactivated by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)

Summary for 5VWO

Entry DOI	10.2210/pdb5vwo/pdb
Related	5VWQ 5VWR
Descriptor	Ornithine aminotransferase, mitochondrial, (1S,3S,4E)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid (3 entities in total)
Functional Keywords	aminotransferase, mechanism-based inactivator, plp, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	135655.81
Authors	Mascarenhas, R.,Liu, D.,Le, H.,Silverman, R. (deposition date: 2017-05-22, release date: 2017-08-30, Last modification date: 2023-10-04)
Primary citation	Mascarenhas, R.,Le, H.V.,Clevenger, K.D.,Lehrer, H.J.,Ringe, D.,Kelleher, N.L.,Silverman, R.B.,Liu, D. Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry, 56:4951-4961, 2017 Cited by PubMed: 28816437 DOI: 10.1021/acs.biochem.7b00499 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.773 Å)

Structure validation