6O7U
| Saccharomyces cerevisiae V-ATPase Stv1-VO | 分子名称: | Putative protein YPR170W-B, V-type proton ATPase subunit a, Golgi isoform, ... | 著者 | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | 登録日 | 2019-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6TXZ
| FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 | 分子名称: | Fab H, Fab L, Hepatitis A virus cellular receptor 2 | 著者 | Musil, D, Sood, V. | 登録日 | 2020-01-15 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Oncoimmunology, 9, 2020
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6OAO
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6OFD
| The crystal structure of octadecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P, Kan, M.W. | 登録日 | 2019-03-29 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur.J.Med.Chem., 182, 2019
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6OQ1
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5WMX
| Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1 | 分子名称: | 2-(1H-indol-3-yl)ethanol, CYANIDE ION, Indoleamine 2,3-dioxygenase 1, ... | 著者 | Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.M. | 登録日 | 2017-07-31 | 公開日 | 2017-12-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8, 2017
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6OPG
| phosphorylated ERK2 with AMP-PNP | 分子名称: | MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Vigers, G.P, Smith, D. | 登録日 | 2019-04-25 | 公開日 | 2019-07-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc.Natl.Acad.Sci.USA, 116, 2019
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1VDY
| NMR Structure of the hypothetical ENTH-VHS domain At3g16270 from Arabidopsis thaliana | 分子名称: | hypothetical protein (RAFL09-17-B18) | 著者 | Lopez-Mendez, B, Pantoja-Uceda, D, Tomizawa, T, Koshiba, S, Kigawa, T, Shirouzu, M, Terada, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Seki, M, Shinozaki, K, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-03-25 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the hypothetical ENTH-VHS domain AT3G16270 from arabidopsis thaliana To be Published
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5WK7
| P450cam mutant R186A | 分子名称: | 5-EXO-HYDROXYCAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... | 著者 | Batabyal, D, Poulos, T.L. | 登録日 | 2017-07-24 | 公開日 | 2017-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.983 Å) | 主引用文献 | Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J. Am. Chem. Soc., 139, 2017
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5WKA
| Crystal structure of a GH1 beta-glucosidase retrieved from microbial metagenome of Poraque Amazon lake | 分子名称: | Beta-glucosidase, DI(HYDROXYETHYL)ETHER, GLYCEROL | 著者 | Morais, M.A.B, Toyama, D, Ramos, F.C, Zanphorlin, L.M, Tonoli, C.C.C, Miranda, F.P, Ruller, R, Henrique-Silva, F, Murakami, M.T. | 登録日 | 2017-07-24 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | A novel beta-glucosidase isolated from the microbial metagenome of Lake Poraque (Amazon, Brazil). Biochim. Biophys. Acta, 1866, 2018
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5WS3
| Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA | 分子名称: | N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, ... | 著者 | Suno, R, Kimura, K, Nakane, T, Yamashita, K, Wang, J, Fujiwara, T, Yamanaka, Y, Im, D, Tsujimoto, H, Sasanuma, M, Horita, S, Hirokawa, T, Nango, E, Tono, K, Kameshima, T, Hatsui, T, Joti, Y, Yabashi, M, Shimamoto, K, Yamamoto, M, Rosenbaum, D.M, Iwata, S, Shimamura, T, Kobayashi, T. | 登録日 | 2016-12-05 | 公開日 | 2017-12-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Structure, 26, 2018
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5WMU
| Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase I | 分子名称: | CYANIDE ION, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L. | 登録日 | 2017-07-31 | 公開日 | 2017-12-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8, 2017
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5WN8
| Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1 | 分子名称: | Indoleamine 2,3-dioxygenase 1, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lewis-Ballester, A, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L, Yeh, S.R. | 登録日 | 2017-07-31 | 公開日 | 2017-12-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8, 2017
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5X07
| Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | 分子名称: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | 著者 | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | 登録日 | 2017-01-20 | 公開日 | 2017-08-16 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site Biochemistry, 56, 2017
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6O6B
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6O72
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state | 分子名称: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-07 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
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6O7T
| Saccharomyces cerevisiae V-ATPase Vph1-VO | 分子名称: | Putative protein YPR170W-B, V-type proton ATPase subunit a, vacuolar isoform, ... | 著者 | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | 登録日 | 2019-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6O9A
| Crystal structure of MqnA complexed with 3-hydroxybenzoic acid | 分子名称: | 3-HYDROXYBENZOIC ACID, ACETATE ION, Chorismate dehydratase | 著者 | Hicks, K.A, Mahanta, N, Naseem, S, Fedoseyenko, D, Begley, T.P, Ealick, S.E. | 登録日 | 2019-03-13 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.326 Å) | 主引用文献 | Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase. Biochemistry, 58, 2019
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6ODC
| Crystal structure of HDAC8 in complex with compound 30 | 分子名称: | (2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide, 1,2-ETHANEDIOL, Histone deacetylase 8, ... | 著者 | Zheng, X, Conti, C, Caravella, J, Zablocki, M.-M, Bair, K, Barczak, N, Han, B, Lancia Jr, D, Liu, C, Martin, M, Ng, P.Y, Rudnitskaya, A, Thomason, J.J, Garcia-Dancey, R, Hardy, C, Lahdenranta, J, Leng, C, Li, P, Pardo, E, Saldahna, A, Tan, T, Toms, A.V, Yao, L, Zhang, C. | 登録日 | 2019-03-26 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors To Be Published
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1W1D
| Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, GOLD ION, ... | 著者 | Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2004-06-21 | 公開日 | 2004-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates Embo J., 23, 2004
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5WB4
| Crystal structure of the TarA wall teichoic acid glycosyltransferase | 分子名称: | N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase, SULFATE ION | 著者 | Kattke, M.D, Cascio, D, Sawaya, M.R, Clubb, R.T. | 登録日 | 2017-06-27 | 公開日 | 2019-01-16 | 最終更新日 | 2019-07-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria. Plos Pathog., 15, 2019
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5WEX
| Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors | 分子名称: | 4-{[(4-fluorophenyl)carbamothioyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | Angeli, A, Tanini, D, Peat, T.S, Di Cesare Mannelli, L, Bartolucci, G, Capperucci, A, Ghelardini, C, Supuran, C.T, Carta, F. | 登録日 | 2017-07-10 | 公開日 | 2017-10-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. ACS Med Chem Lett, 8, 2017
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5WIU
| Structure of the human D4 Dopamine receptor in complex with Nemonapride | 分子名称: | D(4) dopamine receptor, soluble cytochrome b562 chimera, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wacker, D, Wang, S, Levit, A, Che, T, Betz, R.M, McCorvy, J.D, Venkatakrishnan, A.J, Huang, X.-P, Dror, R.O, Shoichet, B.K, Roth, B.L. | 登録日 | 2017-07-20 | 公開日 | 2017-10-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.962 Å) | 主引用文献 | D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science, 358, 2017
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6L4R
| Crystal structure of Enterovirus D68 RdRp | 分子名称: | RdRp | 著者 | Wang, M.L, Li, L, Zhang, Y, Chen, Y.P, Su, D. | 登録日 | 2019-10-21 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.147 Å) | 主引用文献 | Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel. J.Struct.Biol., 211, 2020
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8U0T
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