5WN8

Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1

Summary for 5WN8

Entry DOI	10.2210/pdb5wn8/pdb
Related	5WMU 5WMV 5WMW 5WMX
Descriptor	Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide, ... (4 entities in total)
Functional Keywords	indoleamine 2, 3-dioxygenase 1 tryptophan heme inhibitor epacadostat incb024360, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	97693.28
Authors	Lewis-Ballester, A.,Pham, K.N.,Batabyal, D.,Karkashon, S.,Bonanno, J.B.,Poulos, T.L.,Yeh, S.R. (deposition date: 2017-07-31, release date: 2017-12-06, Last modification date: 2023-10-04)
Primary citation	Lewis-Ballester, A.,Pham, K.N.,Batabyal, D.,Karkashon, S.,Bonanno, J.B.,Poulos, T.L.,Yeh, S.R. Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8:1693-1693, 2017 Cited by PubMed: 29167421 DOI: 10.1038/s41467-017-01725-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation