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PDB: 32 件
7SL6
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BU of 7sl6 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL7
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BU of 7sl7 by Molmil
Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R)
分子名称: Insulin A chain (L13R), Insulin A chain (V3E), Insulin B chain, ...
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL2
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BU of 7sl2 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL3
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BU of 7sl3 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL4
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BU of 7sl4 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL1
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BU of 7sl1 by Molmil
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
分子名称: Insulin A chain, Insulin B chain, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-10-22
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
8SBD
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BU of 8sbd by Molmil
Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
分子名称: Insulin A chain, Insulin B chain
著者Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C.
登録日2023-04-03
公開日2023-08-30
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis of insulin fibrillation.
Sci Adv, 9, 2023
6PXV
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BU of 6pxv by Molmil
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region.
分子名称: Insulin, Insulin receptor
著者Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C.
登録日2019-07-27
公開日2019-09-04
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8, 2019
6PXW
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BU of 6pxw by Molmil
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.
分子名称: Insulin, Insulin receptor
著者Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C.
登録日2019-07-28
公開日2019-09-04
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8, 2019
6PYH
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BU of 6pyh by Molmil
Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.
分子名称: Insulin-like growth factor 1 receptor, Insulin-like growth factor I
著者Li, J, Choi, E, Yu, H.T, Bai, X.C.
登録日2019-07-29
公開日2019-10-23
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural basis of the activation of type 1 insulin-like growth factor receptor.
Nat Commun, 10, 2019
8U4C
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BU of 8u4c by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation.
分子名称: Insulin receptor, Insulin-like growth factor II
著者An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
登録日2023-09-10
公開日2024-03-27
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8VJC
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BU of 8vjc by Molmil
Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation.
分子名称: Insulin-like growth factor II, Isoform Short of Insulin receptor
著者An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
登録日2024-01-06
公開日2024-03-27
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8U4E
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BU of 8u4e by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation.
分子名称: Insulin receptor, Insulin-like growth factor II
著者An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
登録日2023-09-10
公開日2024-03-27
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8VJB
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BU of 8vjb by Molmil
Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation.
分子名称: Insulin-like growth factor II, Isoform Short of Insulin receptor
著者An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
登録日2024-01-06
公開日2024-03-27
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
2BNR
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BU of 2bnr by Molmil
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
分子名称: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ...
著者Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V.
登録日2005-03-31
公開日2005-05-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNQ
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BU of 2bnq by Molmil
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
分子名称: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ...
著者Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V.
登録日2005-03-31
公開日2005-05-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNU
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BU of 2bnu by Molmil
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
分子名称: T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION
著者Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, Van Der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V.
登録日2005-04-04
公開日2005-05-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
8U4B
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BU of 8u4b by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) in the apo state
分子名称: Insulin receptor
著者An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
登録日2023-09-10
公開日2024-03-27
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
7STI
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BU of 7sti by Molmil
Full-length insulin receptor bound with unsaturated insulin WT (1 insulin bound) asymmetric conformation
分子名称: Insulin, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-11-13
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7STJ
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BU of 7stj by Molmil
Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1)
分子名称: Insulin, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-11-14
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7STK
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BU of 7stk by Molmil
Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2)
分子名称: Insulin, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-11-14
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7STH
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BU of 7sth by Molmil
Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound) symmetric conformation
分子名称: Insulin, Insulin receptor
著者Bai, X.C, Choi, E.
登録日2021-11-13
公開日2022-03-30
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
6BNT
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BU of 6bnt by Molmil
Crystal structure of AP2 mu1 adaptin C-terminal domain with IRS-1 peptide
分子名称: AP-2 complex subunit mu, Insulin receptor substrate 1
著者Kikuchi, S, Choi, E, Yu, H.
登録日2017-11-17
公開日2018-11-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling.
Nat Commun, 10, 2019
8EZ0
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BU of 8ez0 by Molmil
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation
分子名称: Insulin, Insulin receptor
著者Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E.
登録日2022-10-29
公開日2022-11-09
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
8EYY
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BU of 8eyy by Molmil
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2
分子名称: Insulin, Insulin receptor
著者Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E.
登録日2022-10-29
公開日2022-11-09
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022

 

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