6CDS
 
 | | Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2 | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Merlin, ... | | Authors: | Chinthalapudi, K, Sharff, A.J, Bricogne, G, Izard, T. | | Deposit date: | 2018-02-09 | | Release date: | 2018-07-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9, 2018
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4PR9
 | | Human Vinculin (residues 891-1066) in complex with PIP | | Descriptor: | GLYCEROL, Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Chinthalapudi, K, Rangarajan, E.S, Patil, D, Izard, T. | | Deposit date: | 2014-03-05 | | Release date: | 2014-12-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Mechanism and function of lipid-directed oligomerization of vinculin
To be Published
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5I4E
 | | Crystal Structure of Human Nonmuscle Myosin 2C motor domain | | Descriptor: | ADP ORTHOVANADATE, MAGNESIUM ION, Myosin-14,Alpha-actinin A | | Authors: | Chinthalapudi, K, Heissler, S.M, Preller, M, Sellers, J.R, Manstein, D.J. | | Deposit date: | 2016-02-11 | | Release date: | 2017-09-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
Elife, 6, 2017
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2PQM
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4AE3
 | | Crystal structure of ammosamide 272:myosin-2 motor domain complex | | Descriptor: | 1,2-ETHANEDIOL, ADP ORTHOVANADATE, AMMOSAMIDE 272, ... | | Authors: | Chinthalapudi, K, Heissler, S.M, Fenical, W, Manstein, D.J. | | Deposit date: | 2012-01-05 | | Release date: | 2013-01-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Ammosamide Mediated Myosin Motor Activity Inhibition
To be Published
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2XEL
 | | Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity | | Descriptor: | 2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | | Authors: | Chinthalapudi, K, Taft, M.H, Martin, R, Hartmann, F.K, Heissler, S.M, Tsiavaliaris, G, Gutzeit, H.O, Knoelker, H.J, Coluccio, L.M, Fedorov, R, Manstein, D.J. | | Deposit date: | 2010-05-16 | | Release date: | 2011-06-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J.Biol.Chem., 286, 2011
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5L0C
 | | Human metavinculin (residues 959-1134) in complex with PIP2 | | Descriptor: | PHOSPHATE ION, Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Chinthalapudi, K, Izard, T. | | Deposit date: | 2016-07-27 | | Release date: | 2016-08-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5L0F
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5L0G
 | | Human metavinculin MVt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2 | | Descriptor: | Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Chinthalapudi, K, Izard, T. | | Deposit date: | 2016-07-27 | | Release date: | 2016-08-31 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5L0D
 | | Human Metavinculin(residues 959-1130) in complex with PIP2 | | Descriptor: | Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Chinthalapudi, K, Izard, T. | | Deposit date: | 2016-07-27 | | Release date: | 2016-08-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5L0H
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5L0I
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5L0J
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7MF3
 | | Structure of the autoinhibited state of smooth muscle myosin-2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light polypeptide 6, ... | | Authors: | Heissler, S.M, Arora, A.S, Billington, N, Sellers, J.R, Chinthalapudi, K. | | Deposit date: | 2021-04-08 | | Release date: | 2022-01-05 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structure of the autoinhibited state of myosin-2.
Sci Adv, 7, 2021
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8COG
 | | Human arginylated beta-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Pinto, C.S, Bakker, S.E, Suchenko, A, Hussain, H, Hatano, T, Sampath, K, Chinthalapudi, K, Mishima, M, Balasubramanian, M. | | Deposit date: | 2023-02-28 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.499 Å) | | Cite: | Structure and physiological investigation of human arginylated beta-actin
To Be Published
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6MFS
 | | Mouse talin1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2) | | Descriptor: | PHOSPHATE ION, Talin-1 fusion, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Izard, T, Chinthalapudi, K, Rangarajan, E.S. | | Deposit date: | 2018-09-12 | | Release date: | 2018-09-26 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6U4K
 | | Human talin2 residues 1-403 | | Descriptor: | Talin-2 | | Authors: | Izard, T, Rangarajan, E.S, Colgan, L, Yasuda, R, Chinthalapudi, K. | | Deposit date: | 2019-08-26 | | Release date: | 2020-07-08 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.555 Å) | | Cite: | A distinct talin2 structure directs isoform specificity in cell adhesion.
J.Biol.Chem., 295, 2020
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8DMY
 | | Cryo-EM structure of cardiac muscle alpha-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | | Authors: | Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. | | Deposit date: | 2022-07-09 | | Release date: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural insights into actin isoforms.
Elife, 12, 2023
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8DNH
 | | Cryo-EM structure of nonmuscle beta-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. | | Deposit date: | 2022-07-11 | | Release date: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Structural insights into actin isoforms.
Elife, 12, 2023
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8DNF
 | | Cryo-EM structure of nonmuscle gamma-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 2, ... | | Authors: | Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. | | Deposit date: | 2022-07-11 | | Release date: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Structural insights into actin isoforms.
Elife, 12, 2023
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8DMX
 | | Cryo-EM structure of skeletal muscle alpha-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. | | Deposit date: | 2022-07-08 | | Release date: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Structural insights into actin isoforms.
Elife, 12, 2023
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2XO8
 | | Crystal Structure of Myosin-2 in Complex with Tribromodichloropseudilin | | Descriptor: | 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | | Authors: | Preller, M, Chinthalapudi, K, Martin, R, Knoelker, H.J, Manstein, D.J. | | Deposit date: | 2010-08-10 | | Release date: | 2011-05-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
J.Med.Chem., 54, 2011
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