6MFS
Mouse talin1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2)
Summary for 6MFS
| Entry DOI | 10.2210/pdb6mfs/pdb |
| Descriptor | Talin-1 fusion, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION, ... (4 entities in total) |
| Functional Keywords | angiogenesis, cell adhesion, integrin activation, phospholipids, phosphoinositides, talin activation |
| Biological source | Mus musculus (Mouse) More |
| Total number of polymer chains | 1 |
| Total formula weight | 44002.00 |
| Authors | Izard, T.,Chinthalapudi, K.,Rangarajan, E.S. (deposition date: 2018-09-12, release date: 2018-09-26, Last modification date: 2023-10-11) |
| Primary citation | Chinthalapudi, K.,Rangarajan, E.S.,Izard, T. The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation. Proc. Natl. Acad. Sci. U.S.A., 115:10339-10344, 2018 Cited by PubMed: 30254158DOI: 10.1073/pnas.1806275115 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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