6JFL
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![BU of 6jfl by Molmil](/molmil-images/mine/6jfl) | Nucleotide-free Mitofusin2 (MFN2) | 分子名称: | CALCIUM ION, GLYCEROL, Mitofusin-2,cDNA FLJ57997, ... | 著者 | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | 登録日 | 2019-02-10 | 公開日 | 2019-11-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.806 Å) | 主引用文献 | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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6JFM
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![BU of 6jfm by Molmil](/molmil-images/mine/6jfm) | Mitofusin2 (MFN2)_T111D | 分子名称: | ACETATE ION, CALCIUM ION, Mitofusin-2,Mitofusin-2 | 著者 | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | 登録日 | 2019-02-10 | 公開日 | 2019-11-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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5Z9X
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![BU of 5z9x by Molmil](/molmil-images/mine/5z9x) | Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 in complex with an RNA substrate | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*GP*CP*CP*CP*AP*UP*UP*AP*G)-3'), SULFATE ION, ... | 著者 | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Gan, J, Cao, C, Huang, Y, Chen, X, Ma, J. | 登録日 | 2018-02-05 | 公開日 | 2018-06-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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5Z9Z
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![BU of 5z9z by Molmil](/molmil-images/mine/5z9z) | The C-terminal RRM domain of Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 (E329A/E330A/E332A) | 分子名称: | CITRATE ANION, Small RNA degrading nuclease 1 | 著者 | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Cao, C, Gan, J, Huang, Y, Chen, X, Ma, J. | 登録日 | 2018-02-05 | 公開日 | 2018-06-27 | 最終更新日 | 2018-10-03 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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8JZS
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![BU of 8jzs by Molmil](/molmil-images/mine/8jzs) | Outward-facing SLC15A4 dimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8JZU
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![BU of 8jzu by Molmil](/molmil-images/mine/8jzu) | SLC15A4_TASL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, TLR adapter,Green fluorescent protein, TSLAA-EGPF tag fusion protein | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8JZR
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![BU of 8jzr by Molmil](/molmil-images/mine/8jzr) | Outward_facing SLC15A4 monomer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, lysosomal transporter,ALFA tag | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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3G5C
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![BU of 3g5c by Molmil](/molmil-images/mine/3g5c) | Structural and biochemical studies on the ectodomain of human ADAM22 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADAM 22, CALCIUM ION | 著者 | Liu, H, Shim, A, Chen, X, He, X. | 登録日 | 2009-02-04 | 公開日 | 2009-08-18 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Structural and biochemical studies on the ectodomain of human ADAM22 J.Biol.Chem., 2009
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8E40
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![BU of 8e40 by Molmil](/molmil-images/mine/8e40) | Full-length APOBEC3G in complex with HIV-1 Vif, CBF-beta, and fork RNA | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, RNA, ... | 著者 | Ito, F, Alvarez-Cabrera, A.L, Liu, S, Yang, H, Shiriaeva, A, Zhou, Z.H, Chen, X.S. | 登録日 | 2022-08-17 | 公開日 | 2023-01-11 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Sci Adv, 9, 2023
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8FY7
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![BU of 8fy7 by Molmil](/molmil-images/mine/8fy7) | SARS-CoV-2 main protease in complex with covalent inhibitor | 分子名称: | 3C-like proteinase nsp5, 4-methoxy-N-[(2S)-4-methyl-1-oxo-1-({(2S)-1-[(3S)-2-oxopyrrolidin-3-yl]but-3-en-2-yl}amino)pentan-2-yl]-1H-indole-2-carboxamide | 著者 | Fried, W, Chen, X.S. | 登録日 | 2023-01-25 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. J.Med.Chem., 66, 2023
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6JFK
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![BU of 6jfk by Molmil](/molmil-images/mine/6jfk) | GDP bound Mitofusin2 (MFN2) | 分子名称: | CITRIC ACID, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | 登録日 | 2019-02-10 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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8FVI
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![BU of 8fvi by Molmil](/molmil-images/mine/8fvi) | Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 | 分子名称: | Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... | 著者 | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | 登録日 | 2023-01-19 | 公開日 | 2023-09-06 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
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6JPJ
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![BU of 6jpj by Molmil](/molmil-images/mine/6jpj) | Crystal structure of FGF401 in complex of FGFR4 | 分子名称: | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION | 著者 | Zhou, Z, Chen, X, Chen, Y. | 登録日 | 2019-03-27 | 公開日 | 2019-05-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.638 Å) | 主引用文献 | Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4. Chem.Commun.(Camb.), 55, 2019
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8JZX
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![BU of 8jzx by Molmil](/molmil-images/mine/8jzx) | SLC15A4 inhibitor complex | 分子名称: | 2-(4-ethoxyphenyl)-N-[3-[(2R)-2-methylpiperidin-1-yl]propyl]quinoline-4-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun, 14, 2023
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7JKS
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![BU of 7jks by Molmil](/molmil-images/mine/7jks) | Crystal structure of vaccine-elicited broadly neutralizing VRC01-class antibody 2411a in complex with HIV-1 gp120 core | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 gp120 core, The heavy chain of antibody 2411a, ... | 著者 | Zhou, T, Chen, X, Kwong, P.D, Mascola, J.R. | 登録日 | 2020-07-28 | 公開日 | 2021-06-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth. Immunity, 54, 2021
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7JKT
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![BU of 7jkt by Molmil](/molmil-images/mine/7jkt) | Crystal structure of vaccine-elicited broadly neutralizing VRC01-class antibody 2413a in complex with HIV-1 gp120 core | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 gp120 core from strain d45-01dG5, ... | 著者 | Zhou, T, Chen, X, Kwong, P.D, Mascola, J.R. | 登録日 | 2020-07-28 | 公開日 | 2021-06-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth. Immunity, 54, 2021
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7UU4
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![BU of 7uu4 by Molmil](/molmil-images/mine/7uu4) | Crystal structure of APOBEC3G complex with ssRNA | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*AP*AP*UP*UP*U)-3'), SULFATE ION, ... | 著者 | Yang, H, Li, S, Chen, X.S. | 登録日 | 2022-04-28 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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7UU3
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![BU of 7uu3 by Molmil](/molmil-images/mine/7uu3) | Crystal structure of APOBEC3G complex with 3'overhangs RNA-Complex | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(*CP*CP*CP*AP*CP*GP*GP*GP*AP*AP*U)-3'), RNA (5'-R(*CP*CP*CP*GP*UP*GP*GP*GP*AP*AP*U)-3'), ... | 著者 | Yang, H, Li, S, Chen, X.S. | 登録日 | 2022-04-28 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.099 Å) | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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7UU5
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![BU of 7uu5 by Molmil](/molmil-images/mine/7uu5) | Crystal structure of APOBEC3G complex with 5'-Overhang dsRNA | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*AP*AP*CP*CP*GP*CP*AP*GP*CP*G)-3'), RNA (5'-R(P*UP*AP*AP*CP*GP*CP*UP*GP*CP*GP*G)-3'), ... | 著者 | Yang, H, Li, S, Chen, X.S. | 登録日 | 2022-04-28 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nat Commun, 13, 2022
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7XUZ
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![BU of 7xuz by Molmil](/molmil-images/mine/7xuz) | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | 分子名称: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | 著者 | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | 登録日 | 2022-05-20 | 公開日 | 2023-11-29 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (3.591 Å) | 主引用文献 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Nucleic Acids Res., 52, 2024
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8SG2
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![BU of 8sg2 by Molmil](/molmil-images/mine/8sg2) | BIVALENT INTERACTIONS OF PIN1 WITH THE C-TERMINAL TAIL OF PKC | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Protein kinase C beta type | 著者 | Dixit, K, Yang, Y, Chen, X.R, Igumenova, T.I. | 登録日 | 2023-04-11 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation. Elife, 13, 2024
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3IQS
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![BU of 3iqs by Molmil](/molmil-images/mine/3iqs) | Crystal structure of the anti-viral APOBEC3G catalytic domain | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | 著者 | Holden, L.G, Prochnow, C, Chang, Y.P, Bransteitter, R, Chelico, L, Sen, U, Stevens, R.C, Goodman, R.F, Chen, X.S. | 登録日 | 2009-08-20 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature, 456, 2008
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3HFH
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![BU of 3hfh by Molmil](/molmil-images/mine/3hfh) | Crystal structure of tandem FF domains | 分子名称: | Transcription elongation regulator 1 | 著者 | Lu, M, Yang, J, Ren, Z, Subir, S, Bedford, M.T, Jacobson, R.H, McMurray, J.S, Chen, X. | 登録日 | 2009-05-11 | 公開日 | 2009-08-18 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150. J.Mol.Biol., 393, 2009
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7F5F
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![BU of 7f5f by Molmil](/molmil-images/mine/7f5f) | SARS-CoV-2 ORF8 S84 | 分子名称: | CALCIUM ION, ORF8 protein | 著者 | Chen, S, Zhou, Z, Chen, X. | 登録日 | 2021-06-22 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses. Front Immunol, 12, 2021
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7VKM
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![BU of 7vkm by Molmil](/molmil-images/mine/7vkm) | Crystal structure of TrkA (G595R) kinase domain | 分子名称: | Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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