8JZX

SLC15A4 inhibitor complex

Summary for 8JZX

Entry DOI	10.2210/pdb8jzx/pdb
EMDB information	36754
Descriptor	lysosomal transporter,ALFA tag,lysosomal transporter, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... (4 entities in total)
Functional Keywords	endolysosomal transporter, protein transport-inhibitor complex, protein transport/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	127400.66
Authors	Zhang, S.S.,Chen, X.D.,Xie, M. (deposition date: 2023-07-06, release date: 2023-09-27, Last modification date: 2023-12-13)
Primary citation	Boeszoermenyi, A.,Bernaleau, L.,Chen, X.,Kartnig, F.,Xie, M.,Zhang, H.,Zhang, S.,Delacretaz, M.,Koren, A.,Hopp, A.K.,Dvorak, V.,Kubicek, S.,Aletaha, D.,Yang, M.,Rebsamen, M.,Heinz, L.X.,Superti-Furga, G. A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun, 14:6626-6626, 2023 Cited by PubMed: 37863876 DOI: 10.1038/s41467-023-42070-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation