8JZX

SLC15A4 inhibitor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	lysosomal transporter,ALFA tag,lysosomal transporter	polymer	581	62274.2	2	UniProt (Q8N697) Pfam (PF00854) In PDB	Homo sapiens (human)
2	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
3	A, B	CHOLESTEROL	non-polymer		386.7	4	Chemie (CLR)
4	A, B	2-(4-ethoxyphenyl)-N-[3-[(2R)-2-methylpiperidin-1-yl]propyl]quinoline-4-carboxamide	non-polymer		431.6	2	Chemie (Q09)

Sequence modifications

A, B: 1 - 290 (UniProt: Q8N697)
A, B: 291 - 303 (PDB: 8JZX)
A, B: 304 - 577 (UniProt: Q8N697)

PDB	External Database	Details
Gly 578	-	expression tag
Ser 579	-	expression tag
Leu 580	-	expression tag
Glu 581	-	expression tag
Val 582	-	expression tag
Leu 583	-	expression tag
Phe 584	-	expression tag
Gln 585	-	expression tag
Gly 586	-	expression tag
Pro 587	-	expression tag
Gly 588	-	expression tag
Gly 589	-	expression tag
Gly 590	-	expression tag
Ser 591	-	expression tag
Gly 592	-	expression tag
Gly 593	-	expression tag
Gly 594	-	expression tag
Ser 595	-	expression tag
Trp 596	-	expression tag
Ser 597	-	expression tag
His 598	-	expression tag
Pro 599	-	expression tag
Gln 600	-	expression tag
Phe 601	-	expression tag
Glu 602	-	expression tag
Lys 603	-	expression tag
Gly 604	-	expression tag
Gly 605	-	expression tag
Gly 606	-	expression tag
Ser 607	-	expression tag
Gly 608	-	expression tag
Gly 609	-	expression tag
Gly 610	-	expression tag
Ser 611	-	expression tag
Trp 612	-	expression tag
Ser 613	-	expression tag
His 614	-	expression tag
Pro 615	-	expression tag
Gln 616	-	expression tag
Phe 617	-	expression tag
Glu 618	-	expression tag
Lys 619	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	124548.5
Non-Polymers*	Number of molecules	8
	Total formula weight	2852.2
All*	Total formula weight	127400.7

*Water molecules are not included.